Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy
文献类型：期刊论文
| 作者 | Zhang Yanxia1,2; Zhang Xiufeng1; Tang Yalin1; Xiang Junfeng1; Tian Mingyue1,3 |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2011-01-28 |
| 卷号 | 69期号:2页码:247-251 |
| 关键词 | Berberine Hydrochloride Jatrorrhizine Palmatine Hydrochloride Bcl-2 Fluorescence Spectroscopy |
| ISSN号 | 0567-7351 |
| 英文摘要 | The interactions between Bcl-2 and three protoberberine alkaloids: berberine hydrochloride, jatrorrhizine and palmatine hydrochloride were studied by fluorescence spectroscopy. The binding constants and the number of binding sites were measured, respectively, and the quenching mechanism was proposed. The results indicated that the protoberberine alkaloids could decrease the intrinsic fluorescence of Bcl-2 mainly through static quenching. By comparing the structures of the three alkaloids, it was found that the binding affinity to Bcl-2 protein increased with molecular flexibility of the alkaloids. |
| 语种 | 英语 |
| WOS记录号 | WOS:000287907800023 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71917]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang Yanxia |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Yanxia,Zhang Xiufeng,Tang Yalin,et al. Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy[J]. ACTA CHIMICA SINICA,2011,69(2):247-251. |
| APA | Zhang Yanxia,Zhang Xiufeng,Tang Yalin,Xiang Junfeng,&Tian Mingyue.(2011).Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy.ACTA CHIMICA SINICA,69(2),247-251. |
| MLA | Zhang Yanxia,et al."Studies of the Interactions between Three Protoberberine Alkaloids and Bcl-2 by Fluorescence Spectroscopy".ACTA CHIMICA SINICA 69.2(2011):247-251. |
入库方式： OAI收割
来源：化学研究所
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