Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity
文献类型：期刊论文
| 作者 | Han Lu; Du Li-Bo; Jia Hong-Ying; Tian Qin; Liu Yang |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2011-05-10 |
| 卷号 | 32期号:5页码:1013-1015 |
| 关键词 | Chitosan Nanoparticle Trolox Anti-oxidation Activity |
| ISSN号 | 0251-0790 |
| 英文摘要 | Antioxidants are restricted for extensive application because of their disadvantages, including poor solubility and unsatisfactory bioavailabilty. Herein, Trolox, an analogue of vitamin E, was firstly encapsulated into chitosan nanoparticles, which were prepared by self-assembling method. The UV-Vis spectrophotometer and atom force microscope were used to characterize Trolox-chitosan nanoparticles. The results show that the uniform sizes of Trolox-chitosan nanoparticles were about 20-40 tins, and the solubility of Trolox was increased about 27 times. Moreover, the anti-oxidation activity of Trolox-chitosan nanoparticles was evaluated by methods of MTT reduction and MDA content detection. It was revealed that Trolox-chitosan nanoparticles showed better ability of protecting RAW264.7 cells from oxidative stress induced by t-BHP than Trolox alone at the same concentration. The present study demonstrated a new strategy for elevating the solubility of antioxidants or drugs and improving their bioavailability by virtue of loading or conjugating them onto nanoparticles. |
| 语种 | 英语 |
| WOS记录号 | WOS:000291175800004 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71955]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu Yang |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han Lu,Du Li-Bo,Jia Hong-Ying,et al. Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2011,32(5):1013-1015. |
| APA | Han Lu,Du Li-Bo,Jia Hong-Ying,Tian Qin,&Liu Yang.(2011).Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,32(5),1013-1015. |
| MLA | Han Lu,et al."Preparation of Novel Trolox-chitosan Nanoparticles and Its Anti-oxidation Activity".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 32.5(2011):1013-1015. |
入库方式： OAI收割
来源：化学研究所
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