Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery
文献类型：期刊论文
| 作者 | Yu, Haijun; Deng, Chao; Tian, Huayu; Lu, Tiancheng; Chen, Xuesi; Jing, Xiabin |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2011-03-10 |
| 卷号 | 11期号:3页码:352-361 |
| 关键词 | Chitosan Gene Delivery Graft Copolymers Non-viral Poly(L-lysine) |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201000283 |
| 英文摘要 | For the success of non-viral gene delivery, it is of great importance to develop gene vectors with high efficiency but low toxicity. We demonstrate that PLL-grafted chitosan copolymers combine the advantages of PLL with its good pDNA-binding ability and of chitosan with its good biocompatibility. The chemo-physical properties of the prepared Chi-g-PLL copolymers are thoroughly characterized. The in vitro transfection study shows that the copolymers have a much higher gene transfer ability than the starting materials chitosan and PLL. A positive correlation between PLL chain lengths and transfection efficiency of the copolymers is found. Our results suggest that these novel Chi-g-PLL copolymers are good candidates for gene delivery in vivo. |
| 语种 | 英语 |
| WOS记录号 | WOS:000288034800005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/71977]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Haijun,Deng, Chao,Tian, Huayu,et al. Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery[J]. MACROMOLECULAR BIOSCIENCE,2011,11(3):352-361. |
| APA | Yu, Haijun,Deng, Chao,Tian, Huayu,Lu, Tiancheng,Chen, Xuesi,&Jing, Xiabin.(2011).Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery.MACROMOLECULAR BIOSCIENCE,11(3),352-361. |
| MLA | Yu, Haijun,et al."Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery".MACROMOLECULAR BIOSCIENCE 11.3(2011):352-361. |
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来源：化学研究所
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