Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters
文献类型：期刊论文
| 作者 | Zhou, Yawen2; Zheng, Li1; Han, Fu2; Zhang, Guangjin1; Mac, Ying3; Yao, Jiannian3; Keita, Bineta4; de Oliveira, Pedro4; Nadjo, Louis4 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2011-02-05 |
| 卷号 | 375期号:1-3页码:97-101 |
| 关键词 | Polyoxometalates Nanocluster Beta-amyloid Inhibition Molecular Interaction |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2010.11.068 |
| 英文摘要 | In this paper, two representative polyoxometalates (POMs), the wheel-shaped Preyssler anion INaP(5)W(30)O(110)](14-) (P5W30) and the Keggin-type anion [H(2)W(12)O(40)](6-) (H2W12) are shown to interact with A beta 1-40 and to inhibit its fibrillization. Circular Dichroism (CD) shows that addition of both POMs dramatically altered the evolution towards the final beta-sheet secondary structure. Atomic force microscopy (AFM) imaging and dynamic light scattering (DLS) experiments converge to indicate very different shapes and dimensions for the complexes formed in the absence and in the presence of the POMs. Finally, isothermal titration calorimetry (ITC) showed that both POMs showed a purely exothermic (Delta H < 0) interaction process. (C) 2010 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000287285500013 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72039]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Guangjin |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Green Proc Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Beijing Technol & Business Univ, Beijing 100048, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci BNLMS, Inst Chem, Beijing 100190, Peoples R China 4.Univ Paris 11, CNRS, UMR 8000, Lab Chim Phys,Grp Electrochim & Photoelectrochim, F-91405 Orsay, France |
| 推荐引用方式 GB/T 7714 | Zhou, Yawen,Zheng, Li,Han, Fu,et al. Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2011,375(1-3):97-101. |
| APA | Zhou, Yawen.,Zheng, Li.,Han, Fu.,Zhang, Guangjin.,Mac, Ying.,...&Nadjo, Louis.(2011).Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,375(1-3),97-101. |
| MLA | Zhou, Yawen,et al."Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 375.1-3(2011):97-101. |
入库方式： OAI收割
来源：化学研究所
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