Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea
文献类型：期刊论文
| 作者 | Zou Xia-Juan1; Zhang Shi-Wei2; Liu Ying2; Liu Zheng-Ming2; Gao Jun-Wei3; Song Qian-Liu3; Pan Yan3; Zhang Jian-Zhao3; Li Xue-Jun3 |
| 刊名 | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 30期号:7页码:1001-1005 |
| 关键词 | Crystal Structure Anti-tumor Metastasis Lewis-lung-carcinoma Model Synthesis 2-amino-1 3 4-thiadiazole Derivatives |
| ISSN号 | 0254-5861 |
| 英文摘要 | The title compound N-1-(1,3,4-thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea (C9H7N4OSCl, M-r = 254.70) was prepared by the reaction of m-chlorophenyl isocyanate with 2-amino-1,3,4-thiadiazole in dry acetonitrile. The effect of the title compound on tumor metastasis was analyzed by Lewis-lung-carcinoma model. The bioassay showed that the title compound significantly reduced the number of lung metastasis. The crystal structure has been determined by X-ray diffraction. The crystal belongs to the monoclinic system, space group P2(1)/c with a = 11.565(2), b = 9.5616(19), c = 10.221(2) angstrom, beta = 111.75(3)degrees, Z = 4, V = 1049.8(4) angstrom(3), D-c = 1.612 Mg/m(3), F(000) = 520, mu(MoKa) = 0.544 mm(-1), R = 0.0468 and wR = 0.0922 for 1236 observed reflections (I > 2 sigma(I)). |
| 语种 | 英语 |
| WOS记录号 | WOS:000293676600011 |
| 出版者 | CHINESE JOURNAL STRUCTURAL CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72111]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zou Xia-Juan |
| 作者单位 | 1.Peking Univ, Med & Healthy Analyt Ctr, Prote Lab, Beijing 100191, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 3.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou Xia-Juan,Zhang Shi-Wei,Liu Ying,et al. Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2011,30(7):1001-1005. |
| APA | Zou Xia-Juan.,Zhang Shi-Wei.,Liu Ying.,Liu Zheng-Ming.,Gao Jun-Wei.,...&Li Xue-Jun.(2011).Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,30(7),1001-1005. |
| MLA | Zou Xia-Juan,et al."Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 30.7(2011):1001-1005. |
入库方式： OAI收割
来源：化学研究所
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