PREPARATION AND CHARACTERIZATION OF PLGA/TiO2 NANO DRUG DELIBERY CARRIERS
文献类型：期刊论文
| 作者 | Zhang Xiumei1; Cai Jing2; Yang Yanan2; Chen Xuesi3; Xie Xuming4 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2011-06-20 |
| 期号 | 6页码:653-660 |
| 关键词 | Tio2 Nano-particles Plga Organic-inorganic Hybrid Drug Control Release |
| ISSN号 | 1000-3304 |
| DOI | 10.3724/SP.J.1105.2011.10154 |
| 英文摘要 | A novel biodegradable PLGA/TiO2 organic-inorganic hybrid nano-material was prepared by the reaction between activated carboxyl-terminated PLGA, which was synthesized by PLGA and succinic anhydride with TEA as catalyzer, and amino-terminated TiO2 nano-particles which were modified by amino propyltriethoxysilane (KH550). The structure and morphology of the materials were characterized by Fourier transform infrared spectroscopy (FTIR), H-1 nuclear magnetic resonance (H-1-NMR), thermogravimetic analysis (TGA), environmental scanning electron microscopy (ESEM) and transmission electron microscopy (TEM) methods. The results showed that the PLGA was grafted successfully on the surface of nano scale TiO2 particles with 14% average grafting; PLGA/TiO2 hybrid nano-material dispersed uniformly in BSA aqueous solution without obvious aggregation and showed a better adsorptivity (81. 3%) to model drug BSA as compared with that(43. 3%) of pure TiO2 nanoparticles. Different kinds of the nanopaticles containing proteins BSA (TiO2-BSA and PLGA/TiO2-BSA) were loaded into polymer microspheres with PLGA as carrier by the solid-in-oil-in-water emulsion method. The drug loading content, entrapment efficiency and drug release in vitro of different drug containing microspheres were tested. The results indicated that the microspheres of PTB/P showed smooth morphologies, high entrapment efficiency 96% and drug loading content 14.6% and decreased burst effect of drug, compared with TB/P microspheres. |
| 语种 | 英语 |
| WOS记录号 | WOS:000292490100013 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72121]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang Xiumei |
| 作者单位 | 1.Jilin Univ, Hosp 1, Dept Radiol, Changchun 130021, Peoples R China 2.Changchun Univ Technol, Inst Chem Engn, Changchun 130012, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 4.Tsinghua Univ, Inst Polymer Sci & Engn, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Xiumei,Cai Jing,Yang Yanan,et al. PREPARATION AND CHARACTERIZATION OF PLGA/TiO2 NANO DRUG DELIBERY CARRIERS[J]. ACTA POLYMERICA SINICA,2011(6):653-660. |
| APA | Zhang Xiumei,Cai Jing,Yang Yanan,Chen Xuesi,&Xie Xuming.(2011).PREPARATION AND CHARACTERIZATION OF PLGA/TiO2 NANO DRUG DELIBERY CARRIERS.ACTA POLYMERICA SINICA(6),653-660. |
| MLA | Zhang Xiumei,et al."PREPARATION AND CHARACTERIZATION OF PLGA/TiO2 NANO DRUG DELIBERY CARRIERS".ACTA POLYMERICA SINICA .6(2011):653-660. |
入库方式： OAI收割
来源：化学研究所
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