Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies
文献类型：期刊论文
| 作者 | Mao, Xiao-Bo1; Wang, Chen-Xuan1,2; Wu, Xing-Kui1; Ma, Xiao-Jing1,3; Liu, Lei1; Zhang, Lan1; Niu, Lin1; Guo, Yuan-Yuan1; Li, Deng-Hua1; Yang, Yan-Lian1 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2011-12-06 |
| 卷号 | 108期号:49页码:19605-19610 |
| ISSN号 | 0027-8424 |
| 关键词 | Amylin Folding Sites Self-assembly Amyloid |
| DOI | 10.1073/pnas.1102971108 |
| 英文摘要 | We report here the identification of the key sites for the beta structure motifs of the islet amyloid polypeptide (IAPP) analogs by using scanning tunneling microscopy (STM). Duplex folding structures in human IAPP(8-37) (hIAPP(8-37)) assembly were observed featuring a hairpin structure. The multiplicity in rIAPP assembly structures indicates the polydispersity of the rat IAPP(8-37) (rIAPP(8-37)) beta-like motifs. The bimodal length distribution of beta structure motifs for rIAPP(8-37) R18H indicates the multiple beta segments linked by turns. The IAPP(8-37) analogs share common structure motifs of IAPP(8-17) and IAPP(26-37) with the most probable key sites at positions around Ser(19)/Ser(20) and Gly(24). These observations reveal the similar amyloid formation tendency in the C and N terminus segments because of the sequence similarity, while the differences in specific amino acids at each key site manifest the effect of sequence variations. The results could be beneficial for studying structural polymorphism of amyloidal peptides with multiple beta structure motifs. |
| 语种 | 英语 |
| 出版者 | NATL ACAD SCIENCES |
| WOS记录号 | WOS:000297683800040 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72147]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Yan-Lian |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Xiao-Bo,Wang, Chen-Xuan,Wu, Xing-Kui,et al. Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(49):19605-19610. |
| APA | Mao, Xiao-Bo.,Wang, Chen-Xuan.,Wu, Xing-Kui.,Ma, Xiao-Jing.,Liu, Lei.,...&Wang, Chen.(2011).Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(49),19605-19610. |
| MLA | Mao, Xiao-Bo,et al."Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.49(2011):19605-19610. |
入库方式： OAI收割
来源：化学研究所
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