Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs
文献类型：期刊论文
| 作者 | Gu, Jingxia2; Cheng, Woei Ping1; Hoskins, Clare3; Lin, Paul Kong Thoo3; Zhao, Lingling2; Zhu, Lijun2; Qu, Xiaozhong2; Yang, Zhenzhong2 |
| 刊名 | JOURNAL OF MICROENCAPSULATION
 |
| 出版日期 | 2011 |
| 卷号 | 28期号:8页码:752-762 |
| 关键词 | Drug Solubilisation Amphiphilic Graft Copolymer Micelle Drug-polymer Interaction |
| ISSN号 | 0265-2048 |
| DOI | 10.3109/02652048.2011.615951 |
| 英文摘要 | The physicochemical compatibility between amphiphilic polymers and hydrophobic drugs has been recognized as an important issue for improving the drug solubilisation in polymeric micelle formulations. In this work, poly-L-lysine (PLL) grafted by cholate pendants as the only hydrophobic moiety were synthesized in order to facilitate the solubilisation of sterol drugs. Results showed that micelles formed by cholate grafted PLL encapsulated significantly higher level of prednisolone and estradiol than palmitoylated PLL micelles, whereas the solubilisation capacity of non-sterol drug (griseofulvin) is inefficient for both polymers. This suggests that higher drug-polymer incorporation can be achieved by the inclusion of hydrophobic moieties with similar architecture as the drugs, i.e. 'drug-like' functional groups, which will be useful for the future design of colloidal systems for the encapsulation of specific drug. |
| 语种 | 英语 |
| WOS记录号 | WOS:000297353300007 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72203]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Cheng, Woei Ping |
| 作者单位 | 1.Univ Hertfordshire, Sch Pharm, Hatfield AL10 9AB, Herts, England 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Robert Gordon Univ, Sch Pharm & Life Sci, Aberdeen AB10 1FR, Scotland |
| 推荐引用方式 GB/T 7714 | Gu, Jingxia,Cheng, Woei Ping,Hoskins, Clare,et al. Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs[J]. JOURNAL OF MICROENCAPSULATION,2011,28(8):752-762. |
| APA | Gu, Jingxia.,Cheng, Woei Ping.,Hoskins, Clare.,Lin, Paul Kong Thoo.,Zhao, Lingling.,...&Yang, Zhenzhong.(2011).Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs.JOURNAL OF MICROENCAPSULATION,28(8),752-762. |
| MLA | Gu, Jingxia,et al."Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs".JOURNAL OF MICROENCAPSULATION 28.8(2011):752-762. |
入库方式： OAI收割
来源：化学研究所
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