Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization
文献类型：期刊论文
| 作者 | Guo, Jinshan1; Wei, Ying1; Zhou, Dongfang1; Cai, Pingqiang2; Jing, Xiabin1; Chen, Xue-Si1; Huang, Yubin1 |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2011-03-01 |
| 卷号 | 12期号:3页码:737-746 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/bm1013662 |
| 英文摘要 | Poly(epsilon-lysine) (epsilon-PL)-analogous click polypeptides with not only similar alpha-amino side groups but also similar main chain to epsilon-PL were chemically synthesized for the first time though click polymerization from aspartic (or glutamic)-acid-based dialkyne and diazide monomers. With microwave-assisting, the reaction time of click polymerization was compressed into 30 min. The polymers were fully characterized by NMR, ATR-FTIR, and SEC-MALLS analysis. The deprotected click polypeptides had similar pK(a) value (7.5) and relatively low cytotoxicity as epsilon-PL and could be used as substitutes of epsilon-PL in biomedical applications, especially in endotoxin selective removal. Poly(ethylene glycol) (PEG)-containing alternating copolymers with a-amino groups were also synthesized and characterized. After deprotection, the polymers could be used as functional gene vector with PEG shadowing system and NCA initiator to get amphiphilic graft polymers. |
| 语种 | 英语 |
| WOS记录号 | WOS:000288183100027 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72471]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Huang, Yubin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Dept Mat Sci & Engn, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Jinshan,Wei, Ying,Zhou, Dongfang,et al. Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization[J]. BIOMACROMOLECULES,2011,12(3):737-746. |
| APA | Guo, Jinshan.,Wei, Ying.,Zhou, Dongfang.,Cai, Pingqiang.,Jing, Xiabin.,...&Huang, Yubin.(2011).Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization.BIOMACROMOLECULES,12(3),737-746. |
| MLA | Guo, Jinshan,et al."Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization".BIOMACROMOLECULES 12.3(2011):737-746. |
入库方式： OAI收割
来源：化学研究所
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