Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent
文献类型：期刊论文
| 作者 | Wang, Tongxin1,2; Chow, Laurence C.3; Frukhtbeyn, Stanislav A.3; Ting, Andy Hai1; Dong, Quanxiao1,2,4; Yang, Mingshu4; Mitchell, James W.1 |
| 刊名 | JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 116期号:5页码:785-796 |
| 关键词 | Bioresorbable Composite Hydroxyapatite Interface Mechanical Pla Polymerization |
| ISSN号 | 1044-677X |
| DOI | 10.6028/jres.116.021 |
| 英文摘要 | Bioresorbable composite made from degradable polymers, e. g., polylactide (PLA), and bioactive calcium phosphates, e. g., hydroxyapatite (HA), are clinically desirable for bone fixation, repair and tissue engineering because they do not need to be removed by surgery after the bone heals. However, preparation of PLA/HA composite from non-modified HA usually results in mechanical strength reductions due to a weak interface between PLA and HA. In this study, a calcium-phosphate/phosphonate hybrid shell was developed to introduce a greater amount of reactive hydroxyl groups onto the HA particles. Then, PLA was successfully grafted on HA by surface-initiated polymerization through the non-ionic surface hydroxyl groups. Thermogravimetric analysis indiated that the amount of grafted PLA on HA can be up to 7 %, which is about 50 % greater than that from the literature. PLA grafted HA shows significantly different pH dependent zeta-potential and particle size profiles from those of uncoated HA. By combining the phosphonic acid coupling agent and surface initiated polymerization, PLA could directly link to HA through covalent bond so that the interfacial interaction in the PLA/HA composite can be significantly improved. The diametral tensile strength of PLA/HA composite prepared from PLA-grafted HA was found to be over twice that of the composite prepared from the non-modified HA. Moreover, the tensile strength of the improved composite was 23 % higher than that of PLA alone. By varying additional variables, this approach has the potential to produce bioresorbable composites with improved mechanical properties that are in the range of natural bones, and can have wide applications for bone fixation and repair in load-bearing areas. |
| 语种 | 英语 |
| WOS记录号 | WOS:000295866500004 |
| 出版者 | US GOVERNMENT PRINTING OFFICE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72493]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Tongxin |
| 作者单位 | 1.Howard Univ, Coll Engn, Washington, DC 20059 USA 2.Howard Univ, Coll Dent, Washington, DC 20059 USA 3.Natl Inst Stand & Technol, Div Polymer, Paffenbarger Res Ctr, Amer Dent Assoc Fdn, Gaithersburg, MD 20899 USA 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Tongxin,Chow, Laurence C.,Frukhtbeyn, Stanislav A.,et al. Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent[J]. JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY,2011,116(5):785-796. |
| APA | Wang, Tongxin.,Chow, Laurence C..,Frukhtbeyn, Stanislav A..,Ting, Andy Hai.,Dong, Quanxiao.,...&Mitchell, James W..(2011).Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent.JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY,116(5),785-796. |
| MLA | Wang, Tongxin,et al."Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent".JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY 116.5(2011):785-796. |
入库方式： OAI收割
来源：化学研究所
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