Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch
文献类型：期刊论文
| 作者 | Zhang, An-Guo1; Zhang, You-Zhuan1; Duan, Zhi-Ming1; Wang, Ke-Zhi1; Wei, Hui-Bo2; Bian, Zu-Qiang2; Huang, Chun-Hui2 |
| 刊名 | INORGANIC CHEMISTRY
 |
| 出版日期 | 2011-07-18 |
| 卷号 | 50期号:14页码:6425-6436 |
| ISSN号 | 0020-1669 |
| DOI | 10.1021/ic102126m |
| 英文摘要 | A new Ru(II) complex of [Ru(phen)(2)(Hcdpq)](ClO(4))(2) {phen = 1,10-phenanthroline, Hcdpq = 2-carboxyl-dipyrido[3,2-f:2',3'-h]quinoxaline} was synthesized and characterized. The spectrophotometric pH and calf thymus DNA (ct-DNA) titrations showed that the complex acted as a dual molecular light switch for pH and ct-DNA with emission enhancement factors of 17 and 26, respectively. It was shown to be capable of distinguishing ct-DNA from yeast RNA with this binding selectivity being superior to two well-known DNA molecular light switches of [Ru(bpy)(2)(dppz)](2+) {bpy =2,2'-bipyridine, and dppz = dipyrido-[3,2-a:2',3'-c]phenazine} and ethidium bromide. The complex bond to ct-DNA probably in groove mode with a binding constant of (4.67 +/- 0.06) x 10(3) M(-1) in 5 mM Tris-HCl, 50 mM NaCl (pH = 7.10) buffer solution, as evidenced by UV-visible absorption and luminescence titrations, the dependence of DNA binding constants on NaCl concentrations, DNA competitive binding with ethidium bromide, and emission lifetime and viscosity measurements. To get insight into the light-switch mechanism, theoretical calculations were also performed by applying density functional theory (DFT) and time-dependent DFT. |
| 语种 | 英语 |
| WOS记录号 | WOS:000292618000007 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72517]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Ke-Zhi |
| 作者单位 | 1.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, An-Guo,Zhang, You-Zhuan,Duan, Zhi-Ming,et al. Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch[J]. INORGANIC CHEMISTRY,2011,50(14):6425-6436. |
| APA | Zhang, An-Guo.,Zhang, You-Zhuan.,Duan, Zhi-Ming.,Wang, Ke-Zhi.,Wei, Hui-Bo.,...&Huang, Chun-Hui.(2011).Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch.INORGANIC CHEMISTRY,50(14),6425-6436. |
| MLA | Zhang, An-Guo,et al."Dual Molecular Light Switches for pH and DNA Based on a Novel Ru(II) Complex. A Non-Intercalating Ru(II) Complex for DNA Molecular Light Switch".INORGANIC CHEMISTRY 50.14(2011):6425-6436. |
入库方式： OAI收割
来源：化学研究所
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