Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes
文献类型：期刊论文
| 作者 | Mo, Guojun1,2; Yue, Jun1,2; Ma, Ping'an1; Chen, Xuesi1; Huang, Yubin1; Jing, Xiabin1 |
| 刊名 | POLYMER INTERNATIONAL
 |
| 出版日期 | 2011-08-01 |
| 卷号 | 60期号:8页码:1269-1276 |
| 关键词 | Amphiphilic Block Polymer Micelles Serinol Amino Groups Carbonate Folic Acid Fluorescein Isothiocyanate (Fitc) |
| ISSN号 | 0959-8103 |
| DOI | 10.1002/pi.3074 |
| 英文摘要 | Amphiphilic amino-bearing biodegradable copolymers, [methoxy-poly(ethylene glycol)]-block-poly[(L-lactide)-co-(serinol carbonate)] (mPEG-block-P(LA-co-CA)), are prepared by synthesizing amino-bearing cyclic carbonate monomer N-benzoxycarbonylserinol carbonate (CAB) starting from serinol, by ring-opening polymerization of L-lactide and CAB using diethylzinc as catalyst and mPEG as macroinitiator, and by subsequent removal of the protective benzyloxycarbonyl groups by HBr treatment. After deprotection, the pendant amino groups on the carbonate units are reacted with N-hydroxylsuccinimide-activated folic acid (FA) to achieve mPEG-block-P(LA-co-CA/FA) conjugate and with fluorescein isothiocyanate (FITC) to achieve mPEG-block-P(LA-co-CA/FITC) conjugate. The structures of mPEG-block-P(LA-co-CAB), mPEG-block-P(LA-co-CA), mPEG-block-P(LA-co-CA/FA) and mPEG-block-P(LA-co-CA/FITC) are confirmed using H-1 NMR and Fourier transform infrared spectroscopy. The block copolymers can self-assemble into micelles in aqueous solution. Because of the functionality of FA and FITC, these copolymers can find important applications in drug delivery systems to serve as targeting moieties and fluorescent probes. (C) 2011 Society of Chemical Industry |
| 语种 | 英语 |
| WOS记录号 | WOS:000293963300018 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72557]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mo, Guojun,Yue, Jun,Ma, Ping'an,et al. Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes[J]. POLYMER INTERNATIONAL,2011,60(8):1269-1276. |
| APA | Mo, Guojun,Yue, Jun,Ma, Ping'an,Chen, Xuesi,Huang, Yubin,&Jing, Xiabin.(2011).Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes.POLYMER INTERNATIONAL,60(8),1269-1276. |
| MLA | Mo, Guojun,et al."Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes".POLYMER INTERNATIONAL 60.8(2011):1269-1276. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。