Toxicity of Nano Gamma Alumina to Neural Stem Cells
文献类型：期刊论文
| 作者 | Dong, Erya1; Wang, Yanli1; Yang, Sheng-Tao1,2; Yuan, Yuan2; Nie, Haiyu2; Chang, Yanli1; Wang, Lin1; Liu, Yuanfang1,2; Wang, Haifang1 |
| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 11期号:9页码:7848-7856 |
| 关键词 | Nanotoxicity Gamma-alumina Stem Cell |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2011.4748 |
| 英文摘要 | Nano alumina, one of the most important nanomaterials, is widely used in diverse areas. It was reported that nano alumina could cross the blood brain barrier to enter the brain. Considering aluminum accumulation in brain is closely related to many neural diseases. We studied the neural toxicity of four nano gamma-alumina samples by using neural stem cells (NSCs) C17.2 as a model. We find that the toxicity of nano gamma-alumina is pretty low, though these alumina particles are easily internalized by cells. The loss of cell viability and membrane integrity are dose-dependent and sample-dependent after alumina exposure. At concentrations lower than 100 mu g/mL, no significant toxicity is observed for all alumina samples. When the concentration reaches 200 mu g/mL, alumina treated cells begin to loss their activities. No culture period effect (up to 3 days) is observed. Very tiny soluble aluminum and the absorption of culture medium ingredients onto alumina particles do not affect the cell viability. Intracellular reactive oxygen species generation may contribute to the cytotoxicity of alumina particles at high concentration, but it does not induce the apoptosis of NSCs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000296209900040 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72605]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Haifang |
| 作者单位 | 1.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Erya,Wang, Yanli,Yang, Sheng-Tao,et al. Toxicity of Nano Gamma Alumina to Neural Stem Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2011,11(9):7848-7856. |
| APA | Dong, Erya.,Wang, Yanli.,Yang, Sheng-Tao.,Yuan, Yuan.,Nie, Haiyu.,...&Wang, Haifang.(2011).Toxicity of Nano Gamma Alumina to Neural Stem Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,11(9),7848-7856. |
| MLA | Dong, Erya,et al."Toxicity of Nano Gamma Alumina to Neural Stem Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 11.9(2011):7848-7856. |
入库方式： OAI收割
来源：化学研究所
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