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Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials

文献类型：期刊论文

作者Zhu, Yingyue1; Chen, Wei1; Qiao, Ruirui2; Wang, Libing1; Xu, Chuanlai1
刊名INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
出版日期2011
卷号8期号:8-9页码:664-678
关键词Single-walled Carbon Nanotubes Swnts Antisense Oligodeoxynucleotides Asodns Gold Nanoparticles Gnps Transfection Vector
ISSN号1475-7435
DOI10.1504/IJNT.2011.041437
英文摘要Introduction, A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Methods, Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. Results, The gold nanoparticles helped to improve both transfection and Raman signal. Conclusions, This vector system can be effective for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.
语种英语
WOS记录号WOS:000295368600005
出版者INDERSCIENCE ENTERPRISES LTD
源URL[http://ir.iccas.ac.cn/handle/121111/72671]  
专题中国科学院化学研究所
通讯作者Xu, Chuanlai
作者单位1.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 10008, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Yingyue,Chen, Wei,Qiao, Ruirui,et al. Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials[J]. INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,2011,8(8-9):664-678.
APA Zhu, Yingyue,Chen, Wei,Qiao, Ruirui,Wang, Libing,&Xu, Chuanlai.(2011).Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials.INTERNATIONAL JOURNAL OF NANOTECHNOLOGY,8(8-9),664-678.
MLA Zhu, Yingyue,et al."Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials".INTERNATIONAL JOURNAL OF NANOTECHNOLOGY 8.8-9(2011):664-678.

入库方式： OAI收割

来源：化学研究所

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