Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion
文献类型：期刊论文
| 作者 | Jin, Jianyu1; Ouyang, Xiangyuan2; Li, Jishan2; Jiang, Jianhui2; Wang, Hao1; Wang, Yongxiang1; Yang, Ronghua1,2 |
| 刊名 | ANALYST
 |
| 出版日期 | 2011 |
| 卷号 | 136期号:18页码:3629-3634 |
| ISSN号 | 0003-2654 |
| DOI | 10.1039/c1an15283a |
| 英文摘要 | Inorganic nanomaterials have generated considerable interest in connection to the design of biosensors. Here we exploit the DNA-induced generation of silver nanoparticles for developing an electrical biosensing protocol for chloride ions. Conjugated with thiol modified oligonucleotide, silver nanoparticles were template-synthesized and immobilized on gold electrode. During cyclic voltammogram (CV) scans, the silver nanoparticles were oxidized at high potential to form a layer of Ag/AgCl complex in the presence of Cl(-), giving off sharp solid state redox signals. Under the optimum condition, the electrode responded to Cl(-) over a dynamic range of 2.0 x 10(-5)-0.01 M, with a detection limit of 5.0 x 10(-6) M. Moreover, the specific solubility product constant-based anion recognition made the electrode applicable at a wide pH range and in complex biological systems. To demonstrate the analytical applications of this sensor in real samples, the Cl(-) concentrations in human urine were measured without any sample pretreatment. Urinary Cl(-) detected by the proposed sensor ranged from 110 to 200 mM, which was comparable to the results obtained by standard silver titration. |
| 语种 | 英语 |
| WOS记录号 | WOS:000294123300009 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72737]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Ronghua |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Hunan Univ, Coll Chem & Chem Engn, Ctr Biomed Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Jianyu,Ouyang, Xiangyuan,Li, Jishan,et al. Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion[J]. ANALYST,2011,136(18):3629-3634. |
| APA | Jin, Jianyu.,Ouyang, Xiangyuan.,Li, Jishan.,Jiang, Jianhui.,Wang, Hao.,...&Yang, Ronghua.(2011).Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion.ANALYST,136(18),3629-3634. |
| MLA | Jin, Jianyu,et al."Nucleic acid-modulated silver nanoparticles: A new electrochemical platform for sensing chloride ion".ANALYST 136.18(2011):3629-3634. |
入库方式： OAI收割
来源：化学研究所
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