Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water
文献类型：期刊论文
| 作者 | Wang, Rui; Chen, Gunag-Tao; Du, Fu-Sheng; Li, Zi-Chen |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2011-06-15 |
| 卷号 | 85期号:1页码:56-62 |
| 关键词 | Peg Poly(L-leucine) Mannose Block Copolymer Self-assembly |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2010.11.012 |
| 英文摘要 | Amphiphilic diblock copolymers composed of poly(ethylene glycol) (PEG) and poly(L-leucine) (PLeu) with mannose at the chain end of PEG were synthesized by a combination of ring-opening polymerization (ROP) and click chemistry. First, an alpha-azido, omega-amino PEG (N(3)-PEG-NH(2)) was synthesized and converted to the corresponding amine hydrochloride (N(3)-PEG-NH(2 center dot)HCl), which was used as a macroinitiator to initiate the ROP of L-leucine-N-carboxyanhydride (Leu-NCA), yielding three amphiphilic block copolymers with different chain lengths of PLeu (N(3)-PEG-b-PLeu). Then, click chemistry of the alkynyl mannose with N(3)-PEG-b-PLeu anchored a mannose moiety to the PEG chain end of the copolymer. The self-assembly behavior of these copolymers in water was investigated using transmission electron microscopy (TEM), laser light scattering (LLS) and circular dichroism (CD). Depending on the copolymer composition and the initial concentration of the copolymer in organic solvent, different morphologies (e.g. spherical micelle, wormlike micelle) were observed. The aggregation behavior was demonstrated to be controlled by secondary structure formation and the hydrophobic interactions of the PLeu segments. With mannose moieties on the surface of the aggregates, these aggregates could bind reversibly the lectin Concanavalin A (Con A). (C) 2010 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000290196100010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72811]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zi-Chen |
| 作者单位 | Peking Univ, BNLMS, Key Lab Polymer Chem & Phys, Minist Educ,Dept Polymer Sci & Engn,Coll Chem & M, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Rui,Chen, Gunag-Tao,Du, Fu-Sheng,et al. Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2011,85(1):56-62. |
| APA | Wang, Rui,Chen, Gunag-Tao,Du, Fu-Sheng,&Li, Zi-Chen.(2011).Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water.COLLOIDS AND SURFACES B-BIOINTERFACES,85(1),56-62. |
| MLA | Wang, Rui,et al."Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water".COLLOIDS AND SURFACES B-BIOINTERFACES 85.1(2011):56-62. |
入库方式： OAI收割
来源：化学研究所
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