Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates
文献类型：期刊论文
| 作者 | Xu, Yingying1; Zhu, Jiadan1; Xiang, Kun1; Li, Yuankai1; Sun, Ronghua1; Ma, Jie2; Sun, Hongfang1; Liu, Yuanfang1,3 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 32期号:36页码:9940-9949 |
| 关键词 | Fullerene c(60) Tuftsin Peritoneal Macrophages Phagocytosis Chemotaxis Mhc Ii |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2011.09.022 |
| 英文摘要 | Immunomodulating peptide tuftsin (Thr-Lys-Pro-Arg) was covalently conjugated to fullerene C(60) by two different ways to prepare NH(2)-tuftsin-C(60) and C(60)-tuftsin-COOH. The two new compounds were intensively characterized. The synthetic C(60)-tuftsin conjugates were assayed for their stability against leucine aminopeptidase degradation. And the immunostimulating activities to murine peritoneal macrophages were investigated in vitro. Compared with the natural tuftsin, significant enhancement of phagocytosis, chemotaxis activities and major histocompatibility complex class II (MHC II) molecule expression were observed in macrophages stimulated by both of the conjugates. The two conjugates also exhibit complete resistance to enzymatic hydrolysis, and they are non-toxic to macrophages in the tested concentrations. On all accounts, these results suggest that the C(60)-tuftsin conjugates can be used as potential candidates of immunomodulators and vaccine adjuvants. (C) 2011 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000296821800039 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/72987]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Sun, Hongfang |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, PUMC, Beijing 100021, Peoples R China 3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yingying,Zhu, Jiadan,Xiang, Kun,et al. Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates[J]. BIOMATERIALS,2011,32(36):9940-9949. |
| APA | Xu, Yingying.,Zhu, Jiadan.,Xiang, Kun.,Li, Yuankai.,Sun, Ronghua.,...&Liu, Yuanfang.(2011).Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates.BIOMATERIALS,32(36),9940-9949. |
| MLA | Xu, Yingying,et al."Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates".BIOMATERIALS 32.36(2011):9940-9949. |
入库方式： OAI收割
来源：化学研究所
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