Fluorescent nanofibrils constructed by self-assembly of a peptide amphiphile with an anionic dye
文献类型：期刊论文
| 作者 | Yu, Defeng; Deng, Manli; He, Chengqian; Fan, Yaxun; Wang, Yilin |
| 刊名 | SOFT MATTER
 |
| 出版日期 | 2011 |
| 卷号 | 7期号:22页码:10773-10779 |
| ISSN号 | 1744-683X |
| DOI | 10.1039/c1sm06222k |
| 英文摘要 | The interaction between a peptide amphiphile C(12)-A beta(11-17) and an anionic dye TPE with aggregation-induced emission (AIE) feature at different pH has been studied. C(12)-A beta(11-17) was constructed by attaching a key fragment of amyloid beta-peptide (A beta(11-17)) to a dodecanoic acid through an amide bond. It was found that highly fluorescent nanofibrils can be constructed through the self-assembly of C(12)-A beta(11-17) with TPE. Moreover, formation, structure and fluorescence intensity of the nanofibrils can be modulated by changing pH and the concentration of C(12)-A beta(11-17). In the solution of 0.05 mM C(12)-A beta(11-17) and 0.05 mM TPE, as the pH decreases, the fluorescence intensity of the mixed solution is invariable at pH > 7.0, then fast increases to the maximum while 4.0 < pH < 7.0, and finally fast decreases at pH < 4.0. Only at pH 4.0-7.0, fluorescent nanofibrils of less than 5 mu m length with the beta-sheet secondary structure are formed upon the addition of TPE molecules. In 1.0mM C(12)-A beta(11-17) solution with 0.05 mM TPE, the fluorescence intensity of the mixed solution keeps increasing as the pH decreases in the pH range of 3.4-11.0, and the mixture forms strongly fluorescent nanotapes of more than 50 mu m length with an ordered beta-sheet structure at pH 3.0 or relatively weaker fluorescent nanoribbons with a random coil structure at pH 10.0. |
| 语种 | 英语 |
| WOS记录号 | WOS:000296388300035 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73117]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Yilin |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Defeng,Deng, Manli,He, Chengqian,et al. Fluorescent nanofibrils constructed by self-assembly of a peptide amphiphile with an anionic dye[J]. SOFT MATTER,2011,7(22):10773-10779. |
| APA | Yu, Defeng,Deng, Manli,He, Chengqian,Fan, Yaxun,&Wang, Yilin.(2011).Fluorescent nanofibrils constructed by self-assembly of a peptide amphiphile with an anionic dye.SOFT MATTER,7(22),10773-10779. |
| MLA | Yu, Defeng,et al."Fluorescent nanofibrils constructed by self-assembly of a peptide amphiphile with an anionic dye".SOFT MATTER 7.22(2011):10773-10779. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。