Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary
文献类型：期刊论文
| 作者 | Fu, Xiaofang; Liu, Yi; Li, Wei; Bai, Yu; Liao, Yiping; Liu, Huwei |
| 刊名 | TALANTA
 |
| 出版日期 | 2011-07-15 |
| 卷号 | 85期号:1页码:813-815 |
| 关键词 | Dissociation Constant Carboxymethyl Chitosan Capillary Coating Capillary Electrophoresis Aristolochic Acid |
| ISSN号 | 0039-9140 |
| DOI | 10.1016/j.talanta.2011.03.088 |
| 英文摘要 | Aristolochic acid-I and aristolochic acid-II have been proved to be the main bioactive and toxic component in Aristolochia plants. As a result, the determination of their dissociation constants, which are important property parameters for weak acids, is highly desired for related pharmacological and toxicological studies. In this work, the dissociation constant values of aristolochic acid-I and aristolochic acid-II were determined by capillary electrophoresis using carboxymethyl chitosan-coated capillary, based on their electrophoretic mobilities by using nonlinear regression as well as linear regression, showing that the two models give comparable results. The data were also compared with those obtained by capillary electrophoresis with polybrene-coated capillary, and no conspicuous difference was observed. The correlation coefficients were all higher than 0.998 for both linear and nonlinear regression model. The pKa values were found to be 3.3 +/- 0.1 for aristolochic acid-I and 3.2 +/- 0.1 for aristolochic acid-II. (C) 2011 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000292848900117 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73157]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Huwei |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci,Inst Analyt Chem, Key Lab Bioorgan Chem & Mol Engn Minist Educ, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Xiaofang,Liu, Yi,Li, Wei,et al. Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary[J]. TALANTA,2011,85(1):813-815. |
| APA | Fu, Xiaofang,Liu, Yi,Li, Wei,Bai, Yu,Liao, Yiping,&Liu, Huwei.(2011).Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary.TALANTA,85(1),813-815. |
| MLA | Fu, Xiaofang,et al."Determination of dissociation constants of aristolochic acid I and II by capillary electrophoresis with carboxymethyl chitosan-coated capillary".TALANTA 85.1(2011):813-815. |
入库方式： OAI收割
来源：化学研究所
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