Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug
文献类型：期刊论文
| 作者 | Tang, Hongwei; Xing, Chengfen; Liu, Libing; Yang, Qiong; Wang, Shu |
| 刊名 | SMALL
 |
| 出版日期 | 2011-05-23 |
| 卷号 | 7期号:10页码:1464-1470 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201002189 |
| 英文摘要 | A new amphiphilic conjugated polythiophene derivative (PT-Boc) is synthesized via Suzuki coupling reaction. The amphiphilic characteristic makes it form nanoaggregates in water, in which hydrophobic moieties come together to form the inner core. The polymer shows good photostability and no toxicity to human lung epithelial (A549) cells even at a high concentration (100 mu g mL(-1)). It therefore meets the crucial requirement for cellular imaging and other biological applications. The anticancer drug cisplatin is used as a model, and is linked to polythiophene to obtain a conjugate 'PT-Pt' by coordinated interactions between cisplatin and the amine groups of the polythiophene side chain. The PT-Pt can be used for monitoring the cellular distribution of cisplatin by fluorescence microscopy. The amphiphilic polythiophene provides a platform for fluorescent imaging of drugs and biological molecules in living cells. |
| 语种 | 英语 |
| WOS记录号 | WOS:000291087900021 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73271]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Libing |
| 作者单位 | Chinese Acad Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Hongwei,Xing, Chengfen,Liu, Libing,et al. Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug[J]. SMALL,2011,7(10):1464-1470. |
| APA | Tang, Hongwei,Xing, Chengfen,Liu, Libing,Yang, Qiong,&Wang, Shu.(2011).Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug.SMALL,7(10),1464-1470. |
| MLA | Tang, Hongwei,et al."Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug".SMALL 7.10(2011):1464-1470. |
入库方式： OAI收割
来源：化学研究所
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