Rose Bengal-Grafted Biodegradable Microcapsules: Singlet-Oxygen Generation and Cancer-Cell Incapacitation
文献类型：期刊论文
| 作者 | Wang, Xiao-Lei1; Zeng, Yu1; Zheng, Yan-Zhen1; Chen, Jian-Feng2; Tao, Xia1; Wang, Ling-Xuan3; Teng, Yan4 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 17期号:40页码:11223-11229 |
| 关键词 | Cancer Microcapsules Rose Bengal Self-assembly Singlet Oxygen |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201100975 |
| 英文摘要 | Rose bengal-grafted chitosan (RB-CHI), synthesized through dehydration between amino and carboxyl functional groups under mild conditions, was coated onto the outer layer of preformed biodegradable microcapsules consisting of sodium alginate and chitosan. The fabricated photosensitive microcapsules were characterized by optical microscopy, scanning electron microscopy, and confocal laser scanning microscopy. The assembled materials maintained intact spherical morphology and thus showed good ability to form thin films. Electron spin resonance spectroscopy allowed direct observation of the generation of singlet oxygen ((1)O(2)) from photosensitive microcapsules under light excitation at about 545 nm. Furthermore, with increasing light radiation, the content of (1)O(2) increased, as detected by a chemical probe. In vitro cellular toxicity assays showed that RB-CHI-coated photosensitive microcapsules exhibit good biocompatibility in darkness and high cytotoxicity after irradiation, and could provide new photoresponsive drug-delivery vehicles. |
| 语种 | 英语 |
| WOS记录号 | WOS:000297013100022 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73287]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tao, Xia |
| 作者单位 | 1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China 2.Beijing Univ Chem Technol, Minist Educ High Grav Engn & Technol, Res Ctr, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Inst Biophys, Prot Sci Core Facil Ctr, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiao-Lei,Zeng, Yu,Zheng, Yan-Zhen,et al. Rose Bengal-Grafted Biodegradable Microcapsules: Singlet-Oxygen Generation and Cancer-Cell Incapacitation[J]. CHEMISTRY-A EUROPEAN JOURNAL,2011,17(40):11223-11229. |
| APA | Wang, Xiao-Lei.,Zeng, Yu.,Zheng, Yan-Zhen.,Chen, Jian-Feng.,Tao, Xia.,...&Teng, Yan.(2011).Rose Bengal-Grafted Biodegradable Microcapsules: Singlet-Oxygen Generation and Cancer-Cell Incapacitation.CHEMISTRY-A EUROPEAN JOURNAL,17(40),11223-11229. |
| MLA | Wang, Xiao-Lei,et al."Rose Bengal-Grafted Biodegradable Microcapsules: Singlet-Oxygen Generation and Cancer-Cell Incapacitation".CHEMISTRY-A EUROPEAN JOURNAL 17.40(2011):11223-11229. |
入库方式： OAI收割
来源：化学研究所
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