Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases
文献类型：期刊论文
| 作者 | Liu, Kun-hui; Wu, Li-dan; Zou, Xiao-ran; Yang, Wen; Du, Qian; Su, Hong-mei |
| 刊名 | CHINESE JOURNAL OF CHEMICAL PHYSICS
 |
| 出版日期 | 2011-10-01 |
| 卷号 | 24期号:5页码:580-585 |
| 关键词 | Tetrachlorobenzoquinone Thymine Uracil Triplet State Hydrogen Abstraction Electron Transfer Laser Flash Photolysis |
| ISSN号 | 1674-0068 |
| DOI | 10.1088/1674-0068/24/05/580-585 |
| 英文摘要 | Pentachlorophenol, a widespread environmental pollutant that is possibly carcinogenic to humans, is metabolically oxidized to tetrachloroquinone (TCBQ) which can result in DNA damage. We have investigated the photochemical. reaction dynamics of TCBQ with two pyrimidine type nucleobases (thymine and uracil) upon UVA (355 nm) excitation using the technique of nanosecond time-resolved laser flash photolysis. It has been found that 355 nm excitation populates TCBQ molecules to their triplet state (3)TCBQ*, which are highly reactive towards thymine or uracil and undergo two parallel reactions, the hydrogen abstraction and electron transfer, leading to the observed photoproducts of TCBQH. and TCBQ.(-) in transient absorption spectra. The concomitantly produced nucleobase radicals and radical cations are expected to induce a series of oxidative or strand cleavage damage to DNA afterwards. By characterizing the photochemical hydrogen abstraction and electron transfer reactions, our results provide potentially important molecular reaction mechanisms for understanding the carcinogenic effects of pentachlorophenol and its metabolites TCBQ. |
| 语种 | 英语 |
| WOS记录号 | WOS:000297139200012 |
| 出版者 | CHINESE PHYSICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73375]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Su, Hong-mei |
| 作者单位 | Chinese Acad Sci, State Key Lab Mol React Dynam, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,et al. Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases[J]. CHINESE JOURNAL OF CHEMICAL PHYSICS,2011,24(5):580-585. |
| APA | Liu, Kun-hui,Wu, Li-dan,Zou, Xiao-ran,Yang, Wen,Du, Qian,&Su, Hong-mei.(2011).Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases.CHINESE JOURNAL OF CHEMICAL PHYSICS,24(5),580-585. |
| MLA | Liu, Kun-hui,et al."Photochemical Hydrogen Abstraction and Electron Transfer Reactions of Tetrachlorobenzoquinone with Pyrimidine Nucleobases".CHINESE JOURNAL OF CHEMICAL PHYSICS 24.5(2011):580-585. |
入库方式： OAI收割
来源：化学研究所
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