Honeycomb Self-Assembled Peptide Scaffolds by the Breath Figure Method
文献类型：期刊论文
| 作者 | Du, Mingchun1; Zhu, Pengli1; Yan, Xuehai1,2; Su, Ying1; Song, Weixing3; Li, Junbai1 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2011-04-01 |
| 卷号 | 17期号:15页码:4238-4245 |
| 关键词 | Breath Figure Peptides Scaffolds Self-assembly Supra-molecular Chemistry |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201003021 |
| 英文摘要 | The self-assembly of molecules into desired architectures is currently a challenging subject for the development of supramolecular chemistry. Here we present a facile "breath figure" assembly process through the use of the self-assembled peptide building block diphenylalanine (L-Phe-L-Phe, FF). Macroporous honeycomb scaffolds were fabricated, and average pore size could be regulated, from (1.00 +/- 0.18) mm to (2.12 +/- 0.47) mu m, through the use of different air speeds. It is indicated that the honeycomb formation is humidity-, solvent-, concentration-, and substrate-dependent. Moreover, water molecules introduced from "breath figure" intervene in the formation of hydrogen bonds during FF molecular self-assembly, which results in a hydrogen bond configuration transition from antiparallel beta sheet to parallel beta sheet. Meanwhile, as a result of the higher polarity of water molecules, the FF molecular array is transformed from laminar stacking into a hexagonal structure. These findings not only elucidate the FF molecule self-assembly process, but also strongly support the mechanism of breath figure array formation. Finally, human embryo skin fibroblast (ESF) culture experiments suggest that FF honeycomb scaffolds are an attractive biomaterial for growth of adherent cells with great potential applications in tissue engineering. |
| 语种 | 英语 |
| WOS记录号 | WOS:000290101500023 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73487]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, Int Joint Lab,BNLMS, Beijing 100190, Peoples R China 2.Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Mingchun,Zhu, Pengli,Yan, Xuehai,et al. Honeycomb Self-Assembled Peptide Scaffolds by the Breath Figure Method[J]. CHEMISTRY-A EUROPEAN JOURNAL,2011,17(15):4238-4245. |
| APA | Du, Mingchun,Zhu, Pengli,Yan, Xuehai,Su, Ying,Song, Weixing,&Li, Junbai.(2011).Honeycomb Self-Assembled Peptide Scaffolds by the Breath Figure Method.CHEMISTRY-A EUROPEAN JOURNAL,17(15),4238-4245. |
| MLA | Du, Mingchun,et al."Honeycomb Self-Assembled Peptide Scaffolds by the Breath Figure Method".CHEMISTRY-A EUROPEAN JOURNAL 17.15(2011):4238-4245. |
入库方式： OAI收割
来源：化学研究所
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