Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila
文献类型：期刊论文
| 作者 | Hou, Qinlong2,3; Jiang, Huoqing1,3; Zhang, Xu2,3; Guo, Chao1,3; Huang, Bo2,3; Wang, Peng2,3; Wang, Tiepeng2,3; Wu, Kaiyuan2; Li, Jian2; Gong, Zhefeng1 |
| 刊名 | NITRIC OXIDE-BIOLOGY AND CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 24期号:1页码:17-24 |
| 关键词 | Nitric Oxide Visual Pattern Memory Formaldehyde Dehydrogenase S-nitrosoglutathione Reductase Drosophila |
| ISSN号 | 1089-8603 |
| DOI | 10.1016/j.niox.2010.09.007 |
| 英文摘要 | Nitric oxide (NO) plays an important role in learning and memory which is essential for animals to adapt to the external environment. However, little is known about the role of NO metabolism in this process. S-nitrosoglutathione reductase (GSNOR) is a key protein in the control of NO metabolism and protein S-nitrosation. To study the relationship between NO metabolism and learning and memory, the expression of gene fdh which is homolog to mammalian GSNOR was modulated by the Gal4/UAS system in Drosophila. The over-expression of the fdh in the central nervous system significantly increased GSNOR activity and induced visual pattern memory defects of Drosophila. The role of fdh in learning and memory was independent of development and was neuron-specific: over-expression of the fdh in the fan-shaped body induced memory defect, while over-expression in the mushroom body did not. The visual pattern memory defect could be rescued by co-expression with exogenous cGMP-dependent protein kinase (PKG). Moreover, fdh over-expression resulted in denitrosation of multiple proteins functionally enriched in vesicle-mediated transport, which is important for learning and memory. These results showed that regulation of NO metabolism plays an important role in learning and memory, and the mechanism may involve both NO-cGMP-PKG signaling pathway and S-nitrosation modification. (C) 2010 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000286714100003 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73525]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Qinlong,Jiang, Huoqing,Zhang, Xu,et al. Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila[J]. NITRIC OXIDE-BIOLOGY AND CHEMISTRY,2011,24(1):17-24. |
| APA | Hou, Qinlong.,Jiang, Huoqing.,Zhang, Xu.,Guo, Chao.,Huang, Bo.,...&Chen, Chang.(2011).Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila.NITRIC OXIDE-BIOLOGY AND CHEMISTRY,24(1),17-24. |
| MLA | Hou, Qinlong,et al."Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila".NITRIC OXIDE-BIOLOGY AND CHEMISTRY 24.1(2011):17-24. |
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来源：化学研究所
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