Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T-1- and T-2-weighted magnetic resonance imaging
文献类型：期刊论文
| 作者 | Hu, Fengqin1; Jia, Qiaojuan2; Li, Yilin2; Gao, Mingyuan2 |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2011-05-17 |
| 卷号 | 22期号:24 |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/0957-4484/22/24/245604 |
| 英文摘要 | The development of new types of high-performance nanoparticulate MR contrast agents with either positive (T-1) or dual-contrast (both positive and negative, T-1 + T-2) ability is of great importance. Here we report a facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T-1- and T-2-weighted MRI. The produced superparamagnetic iron oxide nanoparticles (SPIONs) are of high crystallinity and size uniformity with an average diameter of 5.4 nm, and can be individually dispersed in the physiological buffer with high stability. The SPIONs reveal an impressive saturation magnetization of 94 emu g(-1) Fe3O4, the highest r(1) of 19.7 mM(-1) s(-1) and the lowest r(2)/r(1) ratio of 2.0 at 1.5 T reported so far for PEGylated iron oxide nanoparticles. T-1-and T-2-weighted MR images showed that the SPIONs could not only improve surrounding water proton signals in the T-1-weighted image, but induce significant signal reduction in the T-2-weighted image. The good contrast effect of the SPIONs as T-1 + T-2 dual-contrast agents might be due to its high magnetization, optimal nanoparticle size for T-1 + T-2 dual-contrast agents, high size monodispersity and excellent colloidal stability. In vitro cell experiments showed that the SPIONs have little effect on HeLa cell viability. |
| 语种 | 英语 |
| WOS记录号 | WOS:000290213500025 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73571]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Hu, Fengqin |
| 作者单位 | 1.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Fengqin,Jia, Qiaojuan,Li, Yilin,et al. Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T-1- and T-2-weighted magnetic resonance imaging[J]. NANOTECHNOLOGY,2011,22(24). |
| APA | Hu, Fengqin,Jia, Qiaojuan,Li, Yilin,&Gao, Mingyuan.(2011).Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T-1- and T-2-weighted magnetic resonance imaging.NANOTECHNOLOGY,22(24). |
| MLA | Hu, Fengqin,et al."Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T-1- and T-2-weighted magnetic resonance imaging".NANOTECHNOLOGY 22.24(2011). |
入库方式： OAI收割
来源：化学研究所
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