Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr
文献类型：期刊论文
| 作者 | Wang, Deqian1,2; Shi, Jiyun3; Tan, Junjun1; Jin, Xin1,2; Li, Qinmei1,2; Kang, Honglang1; Liu, Ruigang1; Jia, Bing3; Huang, Yong1,4,5 |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 12期号:5页码:1851-1859 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/bm200194s |
| 英文摘要 | Dextran graft poly (N-methacryloylglycylglycine) copolymer-tyrosine conjugates (dextran-g-PMAGGCONHTyr) were synthesized and characterized. Dynamic light scattering (DLS) results indicated that the graft copolymers are soluble in pH 7.4 PBS and 0.9% saline solutions. The graft copolymers were labeled with I-125, and the labeling stability in 0.9% saline solution was investigated. Pharmacokinetics studies showed a rapid clearance of I-125-labeled graft copolymers from the blood pool. Biodistribution images confirmed the preferable liver and spleen accumulation within 1 h after injection and rapid clearance from all the organs over time. The graft copolymer with molecular weight of 9.8 kDa was eliminated from the kidney significantly faster than those with higher molecular weight. The effect of the numbers of -COOH groups on the graft copolymers on the biodistribution was also investigated. It was found that the graft copolymers with the average number of -COOH groups per glucopyranose unit (DS-COOH) of 0.57 and 0.18 are mainly distributed in liver and spleen at 1 h after injection, whereas the graft copolymer with DS-COOH of 0.07 is mainly accumulated in kidney. |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000290246400051 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73863]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ruigang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China 4.Chinese Acad Sci, Tech Inst Phys & Chem, Nat Res Ctr Engn Plast, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Chem, Lab Cellulose & Lignocellulos Chem, Guangzhou 510650, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Deqian,Shi, Jiyun,Tan, Junjun,et al. Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr[J]. BIOMACROMOLECULES,2011,12(5):1851-1859. |
| APA | Wang, Deqian.,Shi, Jiyun.,Tan, Junjun.,Jin, Xin.,Li, Qinmei.,...&Huang, Yong.(2011).Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr.BIOMACROMOLECULES,12(5),1851-1859. |
| MLA | Wang, Deqian,et al."Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr".BIOMACROMOLECULES 12.5(2011):1851-1859. |
入库方式： OAI收割
来源：化学研究所
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