Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors
文献类型：期刊论文
| 作者 | Wu, Yiran1,2; Chen, Zheng1; Liu, Ying1,2; Yu, Lanlan1; Zhou, Lu1; Yang, Suijia1; Lai, Luhua1,2 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2011-06-01 |
| 卷号 | 19期号:11页码:3361-3366 |
| 关键词 | Quinoline-4-methyl Esters Human Nonpancreatic Secretory Phospholipase a(2) Inhibitor Synthesis Bioassay Molecular Model |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2011.04.039 |
| 英文摘要 | A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA(2) inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 mu M. The structure-inhibition-activity relationships of the compounds were studied using molecular docking. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000290955400007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/73913]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yiran,Chen, Zheng,Liu, Ying,et al. Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(11):3361-3366. |
| APA | Wu, Yiran.,Chen, Zheng.,Liu, Ying.,Yu, Lanlan.,Zhou, Lu.,...&Lai, Luhua.(2011).Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY,19(11),3361-3366. |
| MLA | Wu, Yiran,et al."Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY 19.11(2011):3361-3366. |
入库方式： OAI收割
来源：化学研究所
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