Atomic force microscopy observation of the condensates of the spermidine-DNA complexes
文献类型：期刊论文
| 作者 | Lin, Z; Wang, C; Su, M; Tian, F; Ma, J; Bai, CL |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 1998-08-01 |
| 卷号 | 41期号:4页码:418-423 |
| 关键词 | Toroidal Condensates Spermidine Afm Spiral Wound Process Of Globular Subunits |
| ISSN号 | 1006-9291 |
| 英文摘要 | In vitro investigation on the condensation of DNA induced by naturally occurring polyamines can provide useful insights into the packaging state of DNA in vivo, which is closely related to the mechanism of the self-regulation or self-switching of the gene expression. The present paper reports the high resolution AFM observations of the condensates of spermidine-DNA complexes. It was found that the spermidine can directly condense the DNA into toroidal structures. The formation of this special structure is greatly influenced by the dynamic factors such as the concentrations and the reaction time. Close examination revealed that the toroids were constructed by many particles stacked and squeezed together. Our observations indicate that the dynamic process of the toroid formation may be a spiral wound process of the globular subunits. |
| 语种 | 英语 |
| WOS记录号 | WOS:000075346800011 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/74177]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Bai, CL |
| 作者单位 | Acad Sinica, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Z,Wang, C,Su, M,et al. Atomic force microscopy observation of the condensates of the spermidine-DNA complexes[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,1998,41(4):418-423. |
| APA | Lin, Z,Wang, C,Su, M,Tian, F,Ma, J,&Bai, CL.(1998).Atomic force microscopy observation of the condensates of the spermidine-DNA complexes.SCIENCE IN CHINA SERIES B-CHEMISTRY,41(4),418-423. |
| MLA | Lin, Z,et al."Atomic force microscopy observation of the condensates of the spermidine-DNA complexes".SCIENCE IN CHINA SERIES B-CHEMISTRY 41.4(1998):418-423. |
入库方式： OAI收割
来源：化学研究所
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