Influence of loop sequence on relative stability of bimolecular triplex DNA
文献类型：期刊论文
| 作者 | Yang, LJ; Lee, IS; Wang, C; Liu, MZ; Su, M; Bai, CL |
| 刊名 | SCIENCE IN CHINA SERIES C-LIFE SCIENCES
 |
| 出版日期 | 1998-08-01 |
| 卷号 | 41期号:4页码:381-386 |
| 关键词 | Bimolecular Triplex Loop Sequence Stability Molecular Mechanics |
| ISSN号 | 1006-9305 |
| 英文摘要 | The structures of 20 bimolecular triplexes have been built and simulated by molecular mechanics. The sequence of pyrimidine strand is 5'-dTTCTTTCL(1)TTTL(5)-CTTTTCTT-3', where the five nucleotides underlined compose loop sequences. L-1 and L-5 represent varied residues. The sequences of purine strands are 5'-dGAAAAGAA-3' and the reversed orientation 5'-dAAGPLAAG-3'. The influence of different loop sequences and composition on the relative stability of twenty triplexes have been energetically analyzed. The results indicate that 5'-loop triplexes are more stable than 3'-loop ones and the stacking interaction of purines with their adjacent bases are stronger than that of pyrimidines. The stability of triplexes is mainly determined by the first and last nucleotides in the loop. |
| 语种 | 英语 |
| WOS记录号 | WOS:000075306700007 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/74325]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Bai, CL |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, LJ,Lee, IS,Wang, C,et al. Influence of loop sequence on relative stability of bimolecular triplex DNA[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,1998,41(4):381-386. |
| APA | Yang, LJ,Lee, IS,Wang, C,Liu, MZ,Su, M,&Bai, CL.(1998).Influence of loop sequence on relative stability of bimolecular triplex DNA.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,41(4),381-386. |
| MLA | Yang, LJ,et al."Influence of loop sequence on relative stability of bimolecular triplex DNA".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 41.4(1998):381-386. |
入库方式： OAI收割
来源：化学研究所
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