A method for the preparation of polymeric nanocapsules without stabilizer
文献类型：期刊论文
| 作者 | Lu, Z; Bei, JZ; Wang, SG |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 1999-08-27 |
| 卷号 | 61期号:1-2页码:107-112 |
| 关键词 | Polymeric Nanocapsules W/o/w Emulsion Bovine Serum Albumin Poly(L-lactide) Polycaprolactone-poly(Ethylene Oxide) Block Copolymer (Pce) |
| ISSN号 | 0168-3659 |
| 英文摘要 | In this communication poly(L-lactide) (PLLA) nanocapsules containing bovine serum albumin (BSA) were prepared by means of a modified W/O/W double emulsion technology. A mixture of glycerin and water was used instead of the traditional stabilizer system in the preparation of polymeric nanocapsules. The preliminary results showed that the high viscosity of the mixture and the hydroxyl group of the glycerin were helpful to the formation of the nanocapsules. The prepared nanocapsules had a similar spherical form. By comparison of different polymers of poly(L-lactide) and polycaprolactone-poly(ethylene oxide) block copolymer (PCE), it was found that the entrapment efficiency of the BSA was strongly dependent on the hydrophilicity of the polymer. A lower entrapment efficiency of BSA and nanocapsules with smaller size were obtained when the relative hydrophilic PCE polymer was used as the entrapping material. (C) 1999 Elsevier Science B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000082780600010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/75009]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Inst Chem, PCLCC, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Z,Bei, JZ,Wang, SG. A method for the preparation of polymeric nanocapsules without stabilizer[J]. JOURNAL OF CONTROLLED RELEASE,1999,61(1-2):107-112. |
| APA | Lu, Z,Bei, JZ,&Wang, SG.(1999).A method for the preparation of polymeric nanocapsules without stabilizer.JOURNAL OF CONTROLLED RELEASE,61(1-2),107-112. |
| MLA | Lu, Z,et al."A method for the preparation of polymeric nanocapsules without stabilizer".JOURNAL OF CONTROLLED RELEASE 61.1-2(1999):107-112. |
入库方式： OAI收割
来源：化学研究所
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