Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens
文献类型：期刊论文
| 作者 | Deng, XM; Li, XH; Yuan, ML; Li, XW; Xiong, CD; Huang, ZT; Jia, WX |
| 刊名 | CHINESE JOURNAL OF POLYMER SCIENCE
 |
| 出版日期 | 1999 |
| 卷号 | 17期号:3页码:265-270 |
| 关键词 | Poly-dl-lactide-poly(Ethylene Glycol) Vibrio Cholera Antigen Lanthanum Acetate Microsphere Protective Ratio |
| ISSN号 | 0256-7679 |
| 英文摘要 | Poly-dl-lactide-poly(ethylene glycol) (PELA) triblock copolymers were synthesized with lanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outer membrane protein (OMP) were prepared by a double emulsion W/O/W based on solvent extraction methods. The obtained microspheres showed smooth and spherical surface and their size varied between 0.5 and 5.0 mu m, which are suitable for oral targeting delivery system. The distribution tests in rabbits and mice through scanning electronic micrography and fluorescence microscope indicated that microspheres have successfully reached the immunization-related tissues, such as the liver, spleen and intestinal peyer's patches, following oral administration. The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera. |
| 语种 | 英语 |
| WOS记录号 | WOS:000080631100009 |
| 出版者 | SPRINGER-VERLAG SINGAPORE PTE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/75053]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Deng, XM |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 3.W China Univ Med Sci, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, XM,Li, XH,Yuan, ML,et al. Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens[J]. CHINESE JOURNAL OF POLYMER SCIENCE,1999,17(3):265-270. |
| APA | Deng, XM.,Li, XH.,Yuan, ML.,Li, XW.,Xiong, CD.,...&Jia, WX.(1999).Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens.CHINESE JOURNAL OF POLYMER SCIENCE,17(3),265-270. |
| MLA | Deng, XM,et al."Ring-opening copolymerization of DL-lactide and poly(ethylene glycol) initiated by lanthanum acetate and application of the copolymer as matrix of microspheres containing Vibrio cholera antigens".CHINESE JOURNAL OF POLYMER SCIENCE 17.3(1999):265-270. |
入库方式： OAI收割
来源：化学研究所
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