Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation
文献类型：期刊论文
| 作者 | Yang, LJ; Liu, MZ; Deng, WL; Wang, C; Bai, CL; Kan, LS |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 1999-01-11 |
| 卷号 | 76期号:1页码:25-34 |
| 关键词 | Stability Conformation Hairpin Triplex 5-bromodeoxycytosine |
| ISSN号 | 0301-4622 |
| 英文摘要 | Three triple-helical hairpin DNAs with substitution of 5-bromocytosine for cytosine in different strands have been investigated by molecular mechanics and Raman spectroscopy. The stability of the three substituted triplexes were compared with the corresponding unsubstituted tripler DNA by the molecular mechanics method. Base stacking interactions and strand-strand interactions of each tripler were analyzed in detail. Sugar conformations in these triplexes have been determined by both vibrational spectroscopy and molecular dynamics simulation. The hairpin triplexes with substitution occurring in strand I or both in strands I and III have the main sugar conformation of CS'-endo, while the tripler with substitution occurring in strand III is the combination of C3'-endo and C2'-endo sugar conformation. Theoretical results are basically in agreement with experiments. (C) 1999 Elsevier Science B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000078369400003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/75273]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Bai, CL |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Acad Sinica, Inst Chem, Taipei, Taiwan |
| 推荐引用方式 GB/T 7714 | Yang, LJ,Liu, MZ,Deng, WL,et al. Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation[J]. BIOPHYSICAL CHEMISTRY,1999,76(1):25-34. |
| APA | Yang, LJ,Liu, MZ,Deng, WL,Wang, C,Bai, CL,&Kan, LS.(1999).Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation.BIOPHYSICAL CHEMISTRY,76(1),25-34. |
| MLA | Yang, LJ,et al."Influence of 5-bromodeoxycytosine substitution on triplex DNA stability and conformation".BIOPHYSICAL CHEMISTRY 76.1(1999):25-34. |
入库方式： OAI收割
来源：化学研究所
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