Enzymatic biodegradation of poly(ethylene oxide-b-epsilon-caprolactone) diblock copolymer and its potential biomedical applications
文献类型：期刊论文
| 作者 | Gan, ZH; Jim, TF; Li, M; Yuer, Z; Wang, SG; Wu, C |
| 刊名 | MACROMOLECULES
 |
| 出版日期 | 1999-02-09 |
| 卷号 | 32期号:3页码:590-594 |
| ISSN号 | 0024-9297 |
| 英文摘要 | Water-insoluble poly(ethylene oxide-b-epsilon-caprolactone)(PEO-b-PCL) diblock copolymer (M-w = 1.71 x 10(4) g/mol and W-PEO = 20%) was successfully micronized into small polymeric core-shell nanoparticles (micelles) stable in water via a microphase inversion method. Such formed PEO-b-PCL nanoparticles are biodegradable in the presence of Lipase PS (enzyme). The biodegradation of the PEO-b-PCL nanoparticles, actually, only the hydrophobic PCL core, was monitored by laser Light scattering. The biodegradation extent could he influenced by both the copolymer and enzyme concentrations, while the biodegradation rate was mainly determined by the enzyme concentration. Using pyrene as an imitative drug and fluorescence spectroscopy, we have shown that hydrophobic drugs can be easily loaded into the PCL core in the micronization process, and the biodegradation of the PCL block results in the dissolution of the nanoparticles and the releasing of pyrene molecules because the PEO block is soluble in water. The potential biomedical application of the PEO-b-PCL nanoparticles as a controlled release device has been demonstrated. |
| 语种 | 英语 |
| WOS记录号 | WOS:000078570000009 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/75327]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wu, C |
| 作者单位 | 1.Chinese Univ Hong Kong, Dept Chem, Shatin, NT, Hong Kong 2.Univ Sci & Technol China, Dept Chem Phys, Open Lab Bone Select Chem, Hefei 230026, Anhui, Peoples R China 3.Chinese Acad Sci, Inst Chem, Lab Membranes & Med Polymers, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gan, ZH,Jim, TF,Li, M,et al. Enzymatic biodegradation of poly(ethylene oxide-b-epsilon-caprolactone) diblock copolymer and its potential biomedical applications[J]. MACROMOLECULES,1999,32(3):590-594. |
| APA | Gan, ZH,Jim, TF,Li, M,Yuer, Z,Wang, SG,&Wu, C.(1999).Enzymatic biodegradation of poly(ethylene oxide-b-epsilon-caprolactone) diblock copolymer and its potential biomedical applications.MACROMOLECULES,32(3),590-594. |
| MLA | Gan, ZH,et al."Enzymatic biodegradation of poly(ethylene oxide-b-epsilon-caprolactone) diblock copolymer and its potential biomedical applications".MACROMOLECULES 32.3(1999):590-594. |
入库方式： OAI收割
来源：化学研究所
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