Laser light-scattering studies of poly(caprolactone-b-ethylene oxide-b-caprolactone) nanoparticles and their enzymatic biodegradation
文献类型：期刊论文
| 作者 | Zhao, Y; Hu, TJ; Lv, Z; Wang, SG; Wu, C |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
 |
| 出版日期 | 1999-12-01 |
| 卷号 | 37期号:23页码:3288-3293 |
| 关键词 | Triblock Poly(Caprolactone-b-ethylene Oxide-b-caprolactone) coPolymer Lipase Ps Polymeric Nanoparticles Enzymatic Biodegradation Laser Light Scattering |
| ISSN号 | 0887-6266 |
| 英文摘要 | Water-insoluble triblock poly(caprolactone-b-ethylene oxide-b-caprolactone) (PCL-PEO-PCL) was micronized into narrowly distributed nanoparticles stable in water. Using a combination of static and dynamic laser light scattering (LLS), we characterized the resultant nanoparticles and studied their biodegradation in the presence of enzyme lipase PS. The results revealed that the biodegradation rate was mainly dependent on the enzyme concentration. The scattering intensity decreased as the degradation proceeded, but there was no change in size of the remaining nanoparticles, indicating that the degradation of each particle was fast and the enzyme consumed the nanoparticles individually. We also found that different copolymer compositions, i.e., different PCL-PEO molar ratios, led to different biodegradation rates. The pH and temperature dependence of the biodegradation rate were also studied. All results indicated that the biodegradation rate can be well controlled and the biodegradation essentially involves two processes: adsorption of lipase PS onto the nanoparticles, and enzymatic hydrolysis of the PCL blocks. The biomedical application of the enzymatic biodegradation of the copolymer nanoparticles is also envisioned. (C) 1999 John Wiley & Sons, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000083684400003 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/75363]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wu, C |
| 作者单位 | 1.Univ Sci & Technol China, Dept Chem Phys, Opening Lab Bond Select Chem, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Chem, Lab Membranes & Med Polymers, Beijing 100080, Peoples R China 3.Chinese Univ Hong Kong, Dept Chem, Shatin, NT, Hong Kong |
| 推荐引用方式 GB/T 7714 | Zhao, Y,Hu, TJ,Lv, Z,et al. Laser light-scattering studies of poly(caprolactone-b-ethylene oxide-b-caprolactone) nanoparticles and their enzymatic biodegradation[J]. JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS,1999,37(23):3288-3293. |
| APA | Zhao, Y,Hu, TJ,Lv, Z,Wang, SG,&Wu, C.(1999).Laser light-scattering studies of poly(caprolactone-b-ethylene oxide-b-caprolactone) nanoparticles and their enzymatic biodegradation.JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS,37(23),3288-3293. |
| MLA | Zhao, Y,et al."Laser light-scattering studies of poly(caprolactone-b-ethylene oxide-b-caprolactone) nanoparticles and their enzymatic biodegradation".JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS 37.23(1999):3288-3293. |
入库方式： OAI收割
来源：化学研究所
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