Morphology and biodegradation of microspheres of polyester-polyether block copolymer based on polycaprolactone/polylactide/poly(ethylene oxide)
文献类型：期刊论文
| 作者 | Chen, DR; Chen, HL; Bei, JZ; Wang, SG |
| 刊名 | POLYMER INTERNATIONAL
 |
| 出版日期 | 2000-03-01 |
| 卷号 | 49期号:3页码:269-276 |
| 关键词 | Polycaprolactone/polylactide/poly(Ethylene Oxide) Tri-component Copolymer Microspheres Biodegradation Hydrophilicity Morphology |
| ISSN号 | 0959-8103 |
| 英文摘要 | Porous polylactide/poly(ethylene oxide) (PCEL) were prepared by an emulsification-solvent evaporation technique. The effect of hydrophilicity/hydrophobicity of the polymer on the morphology of the PCEL microspheres was studied and compared with that of polycaprolactone (PCL) and polycaprolactone/poly(ethylene oxide) block copolymer (PCE) microspheres. It was demonstrated by X-ray photoelectron spectroscopy (XPS) that the enrichment of PEO segments on the surface of the microspheres occurred during solvent evaporation of the microdrops and lead to porous structure of the microspheres, The effects of the content and length of PEO segments of the PCEL polymer on the morphology of the microspheres were studied. The degradation behaviour of film-like and microsphere-like PCEL was investigated at pH 7.4 and 37+/-1 degrees C. The shape of the PCEL samples had no obvious effect on the degradation rate of the material and homogeneous degradation was a main process. The degradation rate of PCEL microspheres was enhanced in the presence of the enzyme lipase. H-1 NMR measurements revealed that the PEO content reduced with degradation time because the PEO segment was broken down and dissolved in the medium during degradation. (C) 2000 Society of Chemical Industry. |
| 语种 | 英语 |
| WOS记录号 | WOS:000085651300006 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/75893]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, DR,Chen, HL,Bei, JZ,et al. Morphology and biodegradation of microspheres of polyester-polyether block copolymer based on polycaprolactone/polylactide/poly(ethylene oxide)[J]. POLYMER INTERNATIONAL,2000,49(3):269-276. |
| APA | Chen, DR,Chen, HL,Bei, JZ,&Wang, SG.(2000).Morphology and biodegradation of microspheres of polyester-polyether block copolymer based on polycaprolactone/polylactide/poly(ethylene oxide).POLYMER INTERNATIONAL,49(3),269-276. |
| MLA | Chen, DR,et al."Morphology and biodegradation of microspheres of polyester-polyether block copolymer based on polycaprolactone/polylactide/poly(ethylene oxide)".POLYMER INTERNATIONAL 49.3(2000):269-276. |
入库方式： OAI收割
来源：化学研究所
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