Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro
文献类型：期刊论文
| 作者 | Zhang, XY; Cao, EH; Sun, XG; Bai, CL |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2000-11-01 |
| 卷号 | 45期号:21页码:1959-1963 |
| 关键词 | Human Telomere Quadruplex Conformation Cd Spectrum K++++ Na++++ Cation Concentration |
| ISSN号 | 1001-6538 |
| 英文摘要 | Telomere plays an important role in cellular processes, such as cell aging, death and carcinogenisis. Having special sequences, it can form quadruplex structure in vitro. Circular dichroism (CD) spectroscopic studies show that TTAGGG, (TTAGGG)(2) and (TTAGGG)(4) can all form quadruplex in vitro and exist mainly as parallel quadruplex without metal ions. Both K+ and Na+ can stabilize the tetrameric structure and facilitate the forming of anti-parallel conformation. Furthermore, the conformations of quadruplex can also be affected by sequence length, the nature and concentration of metal ions. |
| 语种 | 英语 |
| WOS记录号 | WOS:000165415400009 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/75979]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Cao, EH |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, XY,Cao, EH,Sun, XG,et al. Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro[J]. CHINESE SCIENCE BULLETIN,2000,45(21):1959-1963. |
| APA | Zhang, XY,Cao, EH,Sun, XG,&Bai, CL.(2000).Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro.CHINESE SCIENCE BULLETIN,45(21),1959-1963. |
| MLA | Zhang, XY,et al."Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro".CHINESE SCIENCE BULLETIN 45.21(2000):1959-1963. |
入库方式： OAI收割
来源：化学研究所
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