Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species
文献类型：期刊论文
| 作者 | Wu, T; Shen, JQ; Song, AM; Chen, S; Zhang, MH; Shen, T |
| 刊名 | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
 |
| 出版日期 | 2000-08-01 |
| 卷号 | 57期号:1页码:14-21 |
| 关键词 | Hypocrellins Photodynamic Action Phototherapeutic Window Active Oxygen Epr Photopotentiation |
| ISSN号 | 1011-1344 |
| 英文摘要 | A novel method has been employed to prepare 2-butylamino-2-demethoxy hypocrellin A (BADMHA) and 3-butylamino-2-demethoxy hypocrellin B (BADMHB). Both compounds exhibit stronger absorption at the phototherapeutic window (600-900: nm). The spin trapping and spin counteraction studies have shown that they are both efficient generators of the active oxygen (O-1(2), O-2(.-)) in the aerobic condition. Under the anaerobic condition they generate non-oxygen free radical (semiquinone radical anion), and the active oxygen mechanism of photosensitization can be converted into cion-oxygen free radical mechanism with the depletion of oxygen. The quantum yields of O-1(2) generation of BADMHA and BADMHB are 0.46 and 0.44, respectively. Both are lower than those of their parent compounds HA and HE. But the productions of superoxide anion are enhanced significantly compared with HA and HE, indicating they are both favorable Type I phototherapeutic agents. (C) 2000 Elsevier Science S.A. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000090033900002 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/76149]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, MH |
| 作者单位 | Chinese Acad Sci, Ctr Mol Sci, Inst Photog Chem, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, T,Shen, JQ,Song, AM,et al. Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2000,57(1):14-21. |
| APA | Wu, T,Shen, JQ,Song, AM,Chen, S,Zhang, MH,&Shen, T.(2000).Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,57(1),14-21. |
| MLA | Wu, T,et al."Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenerations of active oxygen and free radical species".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 57.1(2000):14-21. |
入库方式： OAI收割
来源：化学研究所
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