A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution
文献类型：期刊论文
| 作者 | Wu, C; Jim, TF; Gan, Z; Zhao, Y; Wang, S |
| 刊名 | POLYMER
 |
| 出版日期 | 2000-05-01 |
| 卷号 | 41期号:10页码:3593-3597 |
| 关键词 | Poly(Epsilon-caprolactone) Nanoparticles Enzyme/substrate Complexes Lipase Ps |
| ISSN号 | 0032-3861 |
| 英文摘要 | Water insoluble poly(epsilon-caprolactone) (PCL) was micronized into narrowly distributed stable nanoparticles. The biodegradation of such PCL nanoparticles in the presence of the enzyme, Lipase PS, was monitored by using laser light scattering because the scattering intensity is directly related to the particle concentration. The PCL and enzyme concentration dependence of the biodegradation rate supports a heterogeneous catalytic kinetics in which we have introduced an additional equilibrium between the inactive and active enzyme/substrate complexes. The initial rate equation derived on the basis of this mechanism was used to successfully explain the influence of surfactant, pH and temperature on the enzymatic biodegradation. Our results confirmed that both the adsorption and the enzymatic catalysis were important for the biodegradation of the PCL nanoparticles. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000085388300010 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/76459]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wu, C |
| 作者单位 | 1.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China 2.Univ Sci & Technol China, Open Lab Bondselect Chem, Dept Phys Chem, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, Polymer Phys Lab, Changchun 130022, Peoples R China 4.Chinese Acad Sci, Inst Chem, Lab Membranes & Med Polymers, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, C,Jim, TF,Gan, Z,et al. A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution[J]. POLYMER,2000,41(10):3593-3597. |
| APA | Wu, C,Jim, TF,Gan, Z,Zhao, Y,&Wang, S.(2000).A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution.POLYMER,41(10),3593-3597. |
| MLA | Wu, C,et al."A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(epsilon-caprolactone) nanoparticles in aqueous solution".POLYMER 41.10(2000):3593-3597. |
入库方式： OAI收割
来源：化学研究所
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