New developments in 'pure' direct methods for protein crystallography
文献类型：期刊论文
| 作者 | Hou, YG; Cheng, JX; Zhao, C; Li, LP |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2000 |
| 卷号 | 58期号:7页码:917-921 |
| ISSN号 | 0567-7351 |
| 关键词 | 'pure' Direct Method System Optimization Method Object Function Phase Problem Protein Crystallography |
| 英文摘要 | 'pure' direct method is an ab initio method. Recent advances in ab initio direct methods have enabled the solution of crystal structure of small protein from the type and number of atoms in cell as well as native X - ray date that must be available to atomic resolution, that is, without the use of fragments of known structure or the need to prepare heavy - atom derivatives. An approach that is gaining rapidly in popularity is dual space recycling methods SnB and SHELX - D. They have recently solved the previously known structure of triclinic lysozyme consisting of 1001 non - H protein atoms, none heavier than sulfur. The system optimization method has developed from the integration of systematization, optimization and the probability distribution of structure - invariant. Its program is called SYSTEM - 99.On it there is one effective objective function, which is out of ordinary, according to size of the structure, intensity and extensity of relations between reflections, it divides reflections into many subsystems. Then by means of minimization in objective function, it determines all die phases among subsystem in reciprocal space. The SYSTEM - 99 program was able to solve the structure of trichosanthes root(TCS) that contains with 1914 non - H protein atoms none heavier than sulfur. |
| 语种 | 英语 |
| 出版者 | ACTA CHIMICA SINICA |
| WOS记录号 | WOS:000088279100037 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/76571]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Hou, YG |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, YG,Cheng, JX,Zhao, C,et al. New developments in 'pure' direct methods for protein crystallography[J]. ACTA CHIMICA SINICA,2000,58(7):917-921. |
| APA | Hou, YG,Cheng, JX,Zhao, C,&Li, LP.(2000).New developments in 'pure' direct methods for protein crystallography.ACTA CHIMICA SINICA,58(7),917-921. |
| MLA | Hou, YG,et al."New developments in 'pure' direct methods for protein crystallography".ACTA CHIMICA SINICA 58.7(2000):917-921. |
入库方式： OAI收割
来源：化学研究所
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