Photodynamic action of actinomycin D: an EPR spin trapping study
文献类型：期刊论文
| 作者 | Pan, JX; Liu, Y; Zhang, SP; Tu, TC; Yao, SD; Lin, NY |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
 |
| 出版日期 | 2001-07-02 |
| 卷号 | 1527期号:1-2页码:1-3 |
| 关键词 | Actinomycin d Epr Photodynamic Process |
| ISSN号 | 0304-4165 |
| 英文摘要 | Actinomycin D is one of the most widely studied anticancer antibiotic that binds to both double-stranded and single-stranded DNA, and this binding greatly enhances the DNA photosensitization. By use of electron paramagnetic resonance spin trapping techniques, both superoxide radical anion and the radical anion of actinomycin D were identified as important intermediates in the photodynamic process. A mechanism of electron transfer from a DNA base to excited actinomycin D was proposed. These novel findings may shed new light on Future application of this drug in photodynamic therapy or cleavage of DNA in unique and controllable ways. (C) 2001 Elsevier Science B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000169589500001 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/76763]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yao, SD |
| 作者单位 | 1.Acad Sinica, Shanghai Inst Nucl Res, Lab Radiat Chem, Shanghai 201800, Peoples R China 2.Acad Sinica, Beijing Inst Chem, Beijing 100080, Peoples R China 3.Acad Sinica, Inst Plant Physiol, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, JX,Liu, Y,Zhang, SP,et al. Photodynamic action of actinomycin D: an EPR spin trapping study[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2001,1527(1-2):1-3. |
| APA | Pan, JX,Liu, Y,Zhang, SP,Tu, TC,Yao, SD,&Lin, NY.(2001).Photodynamic action of actinomycin D: an EPR spin trapping study.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1527(1-2),1-3. |
| MLA | Pan, JX,et al."Photodynamic action of actinomycin D: an EPR spin trapping study".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1527.1-2(2001):1-3. |
入库方式： OAI收割
来源：化学研究所
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