An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy
文献类型：期刊论文
| 作者 | Chen, YW; Li, L; Zhang, MH; Shen, T |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2001-05-01 |
| 卷号 | 46期号:10页码:823-827 |
| 关键词 | Meso-tetrahydroxylphenyl Chlorin Photodynamic Therapy Redox Properties Superoxide Anion Radical Fluorescence Quenching |
| ISSN号 | 1001-6538 |
| 英文摘要 | Meso-tetrahydroxylphenyl chlorin (m-THPC) is one of the most efficient prospective sensitizers used in photodynamic therapy (PDT). ESR spectroscopy, fluorescence quenching experiments and cyclic voltammogram measurement were used to study its redox properties. The results showed that the ability of m-THPC generating superoxide radical anions was very strong, and the rate constant of In-THPC fluorescence quenching by oxygen k(q) (O-2) = 1.46 x 10(10) mol(-1).s(-1). The values of fluorescence quenching rate constant of m-THPC by some other electron accepters, such as methyl viologen (MV2+) and anthraquinone (An), were also measured. And they were k(q) (MV2+) = 5.51 x 10(9) mol(-1).s(-1), k(q) (An) = 7.81 x 10(9) mol(-1).s(-1). The oxidation potential of m-THPC was examined to be +0.62 V (vs. NHE) in acetonitrile. All these suggested that m-THPC should be a much stronger electron donor than photofrin, the currently used in clinical photodrug, and may react easily through electron transfer with biological matter to yield various radicals. So it seemed reasonable that the type I reaction may play an important role in the high activity of m-THPC-PDT. |
| 语种 | 英语 |
| WOS记录号 | WOS:000169045500007 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/76815]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, MH |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, YW,Li, L,Zhang, MH,et al. An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy[J]. CHINESE SCIENCE BULLETIN,2001,46(10):823-827. |
| APA | Chen, YW,Li, L,Zhang, MH,&Shen, T.(2001).An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy.CHINESE SCIENCE BULLETIN,46(10),823-827. |
| MLA | Chen, YW,et al."An explanation to the high efficiency of m-THPC (temporfin) used in photodynamic therapy".CHINESE SCIENCE BULLETIN 46.10(2001):823-827. |
入库方式： OAI收割
来源：化学研究所
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