DNA biosensor with high sensitivity amplified by gold nanoparticles
文献类型：期刊论文
| 作者 | Zhao, HQ; Lin, L; Li, JR; Tang, JA; Duan, MX; Jiang, L |
| 刊名 | JOURNAL OF NANOPARTICLE RESEARCH
 |
| 出版日期 | 2001-08-01 |
| 卷号 | 3期号:4页码:321-323 |
| ISSN号 | 1388-0764 |
| 关键词 | Gold Nanoparticles Dna Sensor Quartz Crystal Microbalance (Qcm) Amplification |
| 英文摘要 | A biosensor based on quartz crystal microbalance (QCM) using 50 nm gold nanoparticles as the amplification probe for DNA detection was reported in this paper. It had been found that a DNA detection sensitivity of 10(-14) M could be obtained, which was higher than what has been ever reported using the same method. In the curve of weight increase (Deltam) against the target DNA in solution, a plateau appeared as the concentration of analyte DNA increasing, implying the existence of monolayer of gold nanoparticles binding on the top of target DNA. The high sensitivity was explained not only by the weight of the larger particles, but also the larger area occupied by the larger particles which need less target DNA for their binding. |
| 语种 | 英语 |
| 出版者 | KLUWER ACADEMIC PUBL |
| WOS记录号 | WOS:000173729600009 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77075]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jiang, L |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Colloid & Interface Lab Mol Ctr, Beijing 100101, Peoples R China 2.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, HQ,Lin, L,Li, JR,et al. DNA biosensor with high sensitivity amplified by gold nanoparticles[J]. JOURNAL OF NANOPARTICLE RESEARCH,2001,3(4):321-323. |
| APA | Zhao, HQ,Lin, L,Li, JR,Tang, JA,Duan, MX,&Jiang, L.(2001).DNA biosensor with high sensitivity amplified by gold nanoparticles.JOURNAL OF NANOPARTICLE RESEARCH,3(4),321-323. |
| MLA | Zhao, HQ,et al."DNA biosensor with high sensitivity amplified by gold nanoparticles".JOURNAL OF NANOPARTICLE RESEARCH 3.4(2001):321-323. |
入库方式： OAI收割
来源：化学研究所
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