Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor
文献类型：期刊论文
| 作者 | Xiu, GH; Jiang, L; Li, P |
| 刊名 | BIOTECHNOLOGY AND BIOENGINEERING
 |
| 出版日期 | 2001-07-05 |
| 卷号 | 74期号:1页码:29-39 |
| 关键词 | Immobilized Enzyme Kinetic Resolution Mass-transfer Limitations Fixed-bed Reactor Analytical Solution Orthogonal Collocation Method |
| ISSN号 | 0006-3592 |
| 英文摘要 | A mathematical model has been developed for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor in which the enzyme-catalyzed reaction (the irreversible uni-uni competitive Michaelis-Menten kinetics is chosen as an example) was coupled with intraparticle diffusion, external mass transfer, and axial dispersion. The effects of mass-transfer limitations, competitive inhibition of substrates, deactivation on the enzyme effective enantioselectivity, and the optical purity and yield of the desired product are examined quantitatively over a wide range of parameters using the orthogonal collocation method. For a first-order reaction, an analytical solution is derived from the mathematical model for slab-, cylindrical-, and spherical-enzyme supports. Based on the analytical solution for the steady-state resolution process, a new concise formulation is presented to predict quantitatively the mass-transfer limitations on enzyme effective enantioselectivity and optical purity and yield of the desired product for a continuous steady-state kinetic resolution process in a fixed-bed reactor. (C) 2001 John Wiley & Sons, Inc. Biotechnol Bioeng 74: 29-39, 2001. |
| 语种 | 英语 |
| WOS记录号 | WOS:000169219900004 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77471]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xiu, GH |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Shenyang Inst Chem Technol, Dept Chem Engn, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiu, GH,Jiang, L,Li, P. Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor[J]. BIOTECHNOLOGY AND BIOENGINEERING,2001,74(1):29-39. |
| APA | Xiu, GH,Jiang, L,&Li, P.(2001).Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor.BIOTECHNOLOGY AND BIOENGINEERING,74(1),29-39. |
| MLA | Xiu, GH,et al."Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor".BIOTECHNOLOGY AND BIOENGINEERING 74.1(2001):29-39. |
入库方式： OAI收割
来源：化学研究所
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