Modeling the third loop of short-chain snake venom neurotoxins: Roles of the short-range and long-range interactions
文献类型：期刊论文
| 作者 | Liu, ZJ; Li, WZ; Zhang, HY; Han, YZ; Lai, LH |
| 刊名 | PROTEINS-STRUCTURE FUNCTION AND GENETICS
 |
| 出版日期 | 2001 |
| 卷号 | 42期号:1页码:6-16 |
| 关键词 | Long-range Interactions Loop Modeling Protein Structure Stability Monte Carlo Simulated Annealing Snake Venom Neurotoxin Short-range Interactions |
| ISSN号 | 0887-3585 |
| 英文摘要 | The influence of long-range interactions on local structures is an important issue in understanding protein folding process and protein structure stability, Using short-chain snake venom neurotoxin as a model system, we have studied the conformational properties of eight different loop III sequences either in the environment of one of the short-chain neurotoxin, erabutoxin b (PDB ID 1nxb), or in free state by Monte Carlo simulated annealing method. The surrounding protein structure was found to be crucial in stabilizing the loop conformation. Although all the eight peptides prefer type V beta turn in solution, three of them (KPGI, KPGV, KSGI) turn to type II beta turn and the other five (KKGI, KKGV, KNGI, KQGI, and KRGV) are confined to more rigid type V beta turn conformation in the protein structure. Using flexible tetra-glycine-peptide to screen the backbone conformational space in the protein environment also validates the results, This study shows that long-range interactions do contribute to the stability and the types of conformation for a surface loop in protein, while short-range interactions may only provide candidate conformations, which then have to be filtered by the long-range interactions further. Proteins 2001;42:6-16. (C) 2000 Wiley-Liss, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000166077200002 |
| 出版者 | WILEY-LISS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77557]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lai, LH |
| 作者单位 | 1.Peking Univ, Inst Phys Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, ZJ,Li, WZ,Zhang, HY,et al. Modeling the third loop of short-chain snake venom neurotoxins: Roles of the short-range and long-range interactions[J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS,2001,42(1):6-16. |
| APA | Liu, ZJ,Li, WZ,Zhang, HY,Han, YZ,&Lai, LH.(2001).Modeling the third loop of short-chain snake venom neurotoxins: Roles of the short-range and long-range interactions.PROTEINS-STRUCTURE FUNCTION AND GENETICS,42(1),6-16. |
| MLA | Liu, ZJ,et al."Modeling the third loop of short-chain snake venom neurotoxins: Roles of the short-range and long-range interactions".PROTEINS-STRUCTURE FUNCTION AND GENETICS 42.1(2001):6-16. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。