Butylamino-demethoxy-hypocrellins and photodynamic therapy decreases human cancer in vitro and in vivo
文献类型：期刊论文
| 作者 | Xu, SJ; Chen, S; Zhang, MH; Shen, T; Zhao, YP; Liu, ZW; Wu, YD |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
 |
| 出版日期 | 2001-11-29 |
| 卷号 | 1537期号:3页码:222-232 |
| 关键词 | Hypocrellin Photodynamic Therapy Pancreatic Adenocarcinoma Cancer Electron Paramagnetic Resonance |
| ISSN号 | 0925-4439 |
| 英文摘要 | 2-Butylamino-2-demethoxy-hypocrellin A (BAHA) and B (BARB) are new photosensitizers synthesized by a mild reaction of hypocrellins and butylamine. In BAHA and BAHB, the peri-hydroxylated perylenequinone structure of the parent hypocrellins is preserved and the red absorption is enhanced distinctly. Electron paramagnetic resonance spin trapping measurements and 9,10-diphenylanthracene bleaching studies were used to investigate the photodynamic action of BAHA and BARB in the presence of oxygen. Singlet oxygen (O-1(2)) and superoxide anion radical (O-2(.-)) produced by illuminating BAHA and BARB in aerobic solution have been observed. Compared with hypocrellin A and B, BAHA and BAHB primarily remained able to generate O-1(2) and enhanced distinctly the O-2(.)-generating abilities. The photodynamic action of BAHA and BAHB in the therapy of cancer was investigated in vitro and in vivo. Both in vitro and in vivo results revealed a significant decrease in cancer cell growth. Laser or dye alone had no effect, indicating that intratumor BAHA and laser therapy may prove useful in unresectable cancer. (C) 2001 Elsevier Science B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000172761800005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77621]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, MH |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.PUMC Hosp, CAMS & PUMC, Dept Surg, Beijing 100730, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, SJ,Chen, S,Zhang, MH,et al. Butylamino-demethoxy-hypocrellins and photodynamic therapy decreases human cancer in vitro and in vivo[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2001,1537(3):222-232. |
| APA | Xu, SJ.,Chen, S.,Zhang, MH.,Shen, T.,Zhao, YP.,...&Wu, YD.(2001).Butylamino-demethoxy-hypocrellins and photodynamic therapy decreases human cancer in vitro and in vivo.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1537(3),222-232. |
| MLA | Xu, SJ,et al."Butylamino-demethoxy-hypocrellins and photodynamic therapy decreases human cancer in vitro and in vivo".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1537.3(2001):222-232. |
入库方式： OAI收割
来源：化学研究所
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