Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate
文献类型：期刊论文
| 作者 | Tian, CH; Xu, SJ; Chen, S; Shen, JQ; Zhang, MH; Shen, T |
| 刊名 | FREE RADICAL RESEARCH
 |
| 出版日期 | 2001 |
| 卷号 | 35期号:5页码:543-554 |
| 关键词 | Hypocrellin b Zinc Ion Chelate Electron Paramagnetic Resonance Photodynamic Activity Singlet Oxygen |
| ISSN号 | 1071-5762 |
| 英文摘要 | Hypocrellin B (HB), a perylenequinone derivative, is an efficient phototherapeutic agent. The chelation of HB with Zinc ions (Zn2+) results in a metal chelate (Zn-HB) which exhibits considerable absorption (lambda (max) = 612 nm) in the phototherapeutic window. The structure of this chelate has been characterized by U-V-Vis, IR and mass spectra. The redox potentials of the Zn-HB chelate were E-ox = + 1.1V (vs. SCE) and E-re = -0.7V (vs. SCE) as measured using the circle volt curve. The quantum yield of singlet oxygen generated by the Zn-HB chelate was 0.86, which both the electron spin trap (EPR) method and the chemical trap method show to be about 0.1 higher than that of its parent compound HB. In irradiated oxygen-saturated solutions of Zn-HB chelate, superoxide radical anions and hydroxyl radicals were detected by EPR spectroscopy using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the spin-trapping agent. |
| 语种 | 英语 |
| WOS记录号 | WOS:000172596600009 |
| 出版者 | HARWOOD ACAD PUBL GMBH, TAYLOR & FRANCIS GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77649]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, MH |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, CH,Xu, SJ,Chen, S,et al. Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate[J]. FREE RADICAL RESEARCH,2001,35(5):543-554. |
| APA | Tian, CH,Xu, SJ,Chen, S,Shen, JQ,Zhang, MH,&Shen, T.(2001).Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate.FREE RADICAL RESEARCH,35(5),543-554. |
| MLA | Tian, CH,et al."Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate".FREE RADICAL RESEARCH 35.5(2001):543-554. |
入库方式： OAI收割
来源：化学研究所
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