Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro
文献类型：期刊论文
| 作者 | Xu, SJ; Chen, S; Zhang, MH; Shen, T; Liu, ZW; Zhao, YP; Wu, YD |
| 刊名 | ANTI-CANCER DRUG DESIGN
 |
| 出版日期 | 2001-12-01 |
| 卷号 | 16期号:6页码:271-277 |
| 关键词 | Electron Paramagnetic Resonance Hypocrellin Photodynamic Therapy Singlet Oxygen Superoxide Anion Radical |
| ISSN号 | 0266-9536 |
| 英文摘要 | 2-Cyclohexylamino-2-demethoxy-hypocrellin B (CHAHB) is a new photosensitizer synthesized by the mild reaction between hypocrellin B (HB) and cyclohexylamine, in which the perihydroxylated perylenequinone structure of the parent HB is preserved and the photoresponse is enhanced markedly. Electron paramagnetic resonance (EPR) spin trapping measurements and 9,10-diphenylanthracene (DPA) bleaching studies were employed to investigate the photodynamic action of CHAHB in the presence of oxygen. Singlet oxygen (O-1(2)) and superoxide anion radical (O-2(.-)) generated by illuminating CHAHB in aerobic solution have been observed. Compared with HB, CHAHB distinctly enhanced the O-2(.-)-generating abilities, although O-1(2)-generating abilities were lowered. The photodynamic action of CHAHB in the therapy of cancer was investigated in vitro. The results in vitro revealed a much more significant decrease in cancer cell growth than with HB. Laser or dye alone had no effect, indicating that intratumor CHAHB and laser therapy may prove useful in unresectable cancer. |
| 语种 | 英语 |
| WOS记录号 | WOS:000178032500002 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77745]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, MH |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Chinese Acad Med Sci, PUMC Hosp, Dept Surg, Beijing 100730, Peoples R China 3.PUMC, Beijing 100730, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, SJ,Chen, S,Zhang, MH,et al. Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro[J]. ANTI-CANCER DRUG DESIGN,2001,16(6):271-277. |
| APA | Xu, SJ.,Chen, S.,Zhang, MH.,Shen, T.,Liu, ZW.,...&Wu, YD.(2001).Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro.ANTI-CANCER DRUG DESIGN,16(6),271-277. |
| MLA | Xu, SJ,et al."Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro".ANTI-CANCER DRUG DESIGN 16.6(2001):271-277. |
入库方式： OAI收割
来源：化学研究所
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