Prolongation of corneal allograft survival using cyclosporine in a polylactide-co-glycolide polymer
文献类型：期刊论文
| 作者 | Xie, LX; Shi, WY; Wang, ZY; Bei, JZ; Wang, SG |
| 刊名 | CORNEA
 |
| 出版日期 | 2001-10-01 |
| 卷号 | 20期号:7页码:748-752 |
| 关键词 | Corneal Allografts Cyclosporine Immune Suppression Polymer |
| ISSN号 | 0277-3740 |
| 英文摘要 | Purpose. To test for prolongation of corneal transplant survival with cyclosporine in a polymer placed in the anterior chamber of corneal allograft recipients. Methods. Wistar inbred rats with vascularized corneas were recipients of corneal allografts from Sprague-Dawley donor rats. Grafted rats were randomized into six groups: untreated control animals, cyclosporine-polymer anterior chamber recipients, cyclosporine-polymer subconjunctival recipients, cyclosporine-olive oil drop recipients, polymer-only anterior chamber recipients, and autografted Wistar rats. Grafts were examined by slit lamp every 3 days and the clinical condition scored. The cyclosporine concentration in the aqueous humor was assayed at 1, 2, and 4 weeks. At 2 and 4 weeks after transplantation, the eyes were collected for histopathologic evaluation of the grafts. Results. The median survival time of untreated corneal allografts was 8.2 +/- 1.48 days for grafts treated with topical cyclosporine, 8.5 +/- 1.50 days for polymer-only anterior chamber implants, 10.6 +/- 1.90 days for 1% cyclosporine drops, 11.4 +/- 2.50 days for grafts given subconjunctival cyclosporine-polymer, 17 +/- 3.05 days for grafts given cyclosporine-polymer implants in the anterior chamber, and more than 3 months in autografted rats. There was a statistically significant difference (p < 0.05) between the survival time of the allografts in the animals treated with the cyclosporine-polymer in the anterior chamber compared with the other groups of graft recipients. Significantly higher concentrations of cyclosporine were found in the eyes given an anterior chamber implant of cyclosporine-polymer than in the other treatment groups or the untreated rats. The cyclosporine-polymer implants placed in the anterior chamber induced a transient inflammatory response in transplanted eyes. Conclusions. Cyclosporine-polymer placed in the anterior chamber significantly prolongs corneal allograft survival in a high-risk corneal graft rejection. This intraocular delivery system may be a valuable adjunct for the suppression of immune graft rejection in high-risk recipients of corneal transplants. |
| 语种 | 英语 |
| WOS记录号 | WOS:000172221300015 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77863]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xie, LX |
| 作者单位 | 1.Shandong Eye Inst & Hosp, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, LX,Shi, WY,Wang, ZY,et al. Prolongation of corneal allograft survival using cyclosporine in a polylactide-co-glycolide polymer[J]. CORNEA,2001,20(7):748-752. |
| APA | Xie, LX,Shi, WY,Wang, ZY,Bei, JZ,&Wang, SG.(2001).Prolongation of corneal allograft survival using cyclosporine in a polylactide-co-glycolide polymer.CORNEA,20(7),748-752. |
| MLA | Xie, LX,et al."Prolongation of corneal allograft survival using cyclosporine in a polylactide-co-glycolide polymer".CORNEA 20.7(2001):748-752. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。