Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical
文献类型：期刊论文
| 作者 | Ma, JH; Zhao, JQ; Jiang, LJ |
| 刊名 | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
 |
| 出版日期 | 2001-08-30 |
| 卷号 | 61期号:3页码:122-128 |
| 关键词 | Photodynamic Therapy Semiquinone Anion Radical Electron Paramagnetic Resonance Aluminium Ion-complexed 5 8-di-br-hb |
| ISSN号 | 1011-1344 |
| 英文摘要 | In order to improve the photo sensitizing activity of HB further, the complex of 5,8-di-Br-HB with Al3+ was first designed and synthesized in high yield. 5,8-di-Br-HB forms a 2:1 type (metal-ligand ratio) complex with Al3+ measured by molar ratio and continuous variation methods. The new photosensitizer was characterized by UV-Vis, IR, H-1 NMR and elemental analysis measurements. Based on the above experimental results, we first proposed a polymer-like structural model of the complex. The water-solubility and red absorption of the [Al-2(5,8-di-Br-HB)Cl-4](n) complex are both enhanced over hypocrellin B. In addition, the EPR and spectrophotometric measurements demonstrate that semiquinone anion radical of [Al-2(5,8-di-Br-HB)Cl-4](n) can be produced by [Al,(5,8-di-Br-HB)Cl-4], photosensitization. The generation efficiency of {[Al-2(5,8-di-Br-HB)Cl-4](n)}(.-) is almost equal to that of HB.-. These results obtained indicated that [Al-2(5,8-di-Br-HB)Cl-4](n) was at least a favorable Type I photo therapeutic agent. (C) 2001 Published by Elsevier Science B.V. |
| 语种 | 英语 |
| WOS记录号 | WOS:000171085500005 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77927]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, JQ |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, JH,Zhao, JQ,Jiang, LJ. Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2001,61(3):122-128. |
| APA | Ma, JH,Zhao, JQ,&Jiang, LJ.(2001).Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,61(3),122-128. |
| MLA | Ma, JH,et al."Synthesis of a novel hypocrellin B derivative and its photogeneration of semiquinone anion radical".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 61.3(2001):122-128. |
入库方式： OAI收割
来源：化学研究所
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