Enantioselective biotransformations of racemic 2-aryl-3-methylbutyronitriles using Rhodococcus sp AJ270
文献类型：期刊论文
| 作者 | Wang, MX; Li, JJ; Ji, GJ; Li, JS |
| 刊名 | JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
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| 出版日期 | 2001-07-06 |
| 卷号 | 14期号:4-6页码:77-83 |
| 关键词 | Enantioselective Biotransformations 2-aryl-3-methylbutyronitriles S-(+)-2-aryl-3-methylbutyric Acids R-(-)-2-aryl-3-methylbutyramides |
| ISSN号 | 1381-1177 |
| 英文摘要 | Rhodococcus sp. AJ270 is a useful biocatalyst for the synthesis of some enantiopure S-(+)-2-aryl-3-methylbutyric acids and R-(+)-2-aryl-3-methylbutyramides from the hydrolysis of 2-aryl-3-methylbutyronitriles under mild conditions. The nitrile-hydrolyzing enzymes involved in this novel microorganism are very sensitive to the steric effect of the para-substituent on the aromatic ring. While the nitrile hydratase displays a low S-enantioselectivity against nitriles, the amidase has a strict S-enantioselectivity against 2-aryl-3-methylbutyramides. (C) 2001 Elsevier Science B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000169767400002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/77931]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, MX |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, MX,Li, JJ,Ji, GJ,et al. Enantioselective biotransformations of racemic 2-aryl-3-methylbutyronitriles using Rhodococcus sp AJ270[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2001,14(4-6):77-83. |
| APA | Wang, MX,Li, JJ,Ji, GJ,&Li, JS.(2001).Enantioselective biotransformations of racemic 2-aryl-3-methylbutyronitriles using Rhodococcus sp AJ270.JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,14(4-6),77-83. |
| MLA | Wang, MX,et al."Enantioselective biotransformations of racemic 2-aryl-3-methylbutyronitriles using Rhodococcus sp AJ270".JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 14.4-6(2001):77-83. |
入库方式： OAI收割
来源：化学研究所
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